Inhibition of ITK differentiates GVT and GVHD in allo-HSCT
M. Karimi, M. Mammadli, W. Huang, R. Harris, A. Sultana, Y. Cheng, W. Tong, J. Pu, T. Gentile, J. L. Henty-Ridilla, S. Dsouza, Q. Yang, A. August, A. Bah
This paper shows that inhibiting ITK in donor T cells reduces GVHD while preserving GVT effects in allo-HSCT using murine models and a novel peptide inhibitor.
bioRxiv · Jul 15, 2020 · PreprintImmunology