S. Raju

Altered DNA methylation pattern contributes to differential epigenetic immune signaling in the upper respiratory airway of COVID-19 patients

This study identifies altered DNA methylation patterns in the upper respiratory airway of COVID-19 patients, highlighting changes in immune-related genes and potential implications for airway health.

Prototype mRNA vaccines imprint broadly neutralizing human serum antibodies after Omicron variant-matched boosting

This study shows that Omicron variant-matched boosters after prototype mRNA vaccines induce cross-neutralizing antibodies against SARS-CoV-2 and sarbecoviruses by imprinting prior immune responses.

Structural and functional basis of VLDLR receptor usage by Eastern equine encephalitis virus

This study identifies multiple VLDLR binding sites used by EEEV and develops a decoy receptor to neutralize infection.

Oryza genera-specific novel Histone H4 variant predisposes H4 Lysine5 Acetylation marks to modulate salt stress responses

The paper identifies a novel histone H4 variant in Oryza that modulates salt stress responses through chromatin remodeling and acetylation marks.

Wound induced small-peptide mediated signalling cascade regulated by OsPSKR, dictates balance between growth and defense in rice

The paper identifies a peptide-mediated signaling cascade in rice regulated by OsPSKR that balances growth and defense responses during wounding.

Endothelial cells secrete small extracellular vesicles bidirectionally containing distinct cargo to uniquely reprogram vascular cells in the circulation and vessel wall

This study shows endothelial cells release distinct extracellular vesicles to reprogram monocytes and smooth muscle cells in circulation and vessel wall.

Behavioral dissection of hunger states in Drosophila

The paper distinguishes hedonic and homeostatic hunger states in Drosophila by analyzing behaviors and neuronal activity, identifying the PAM to β MB circuit as involved in hedonic feeding motivation.

Biochemical characterization of a Mycobacterium tuberculosis prolyl dipeptidyl peptidase that displays a remarkable thermostability

This study characterizes a Mycobacterium tuberculosis dipeptidyl peptidase with high thermal stability and shows its potential role in immune modulation.

BCL6-dependent TCF-1+ progenitor cells maintain effector and helper CD4 T cell responses to persistent antigen

An intranasal vaccine durably protects against SARS-CoV-2 variants in mice

This study shows that an intranasal vaccine provides durable protection against SARS-CoV-2 variants in mice, including emerging strains like B.1.351 and B.1.1.28.

A potently neutralizing anti-SARS-CoV-2 antibody inhibits variants of concern by binding a highly conserved epitope

The paper identifies an antibody that neutralizes all SARS-CoV-2 variants by targeting a conserved epitope on the spike protein.

Latent Plasticity of Effector-like Exhausted CD8 T cells contributes to memory responses

The paper identifies a subset of exhausted CD8 T cells with plasticity to reprogram into memory cells, suggesting new targets for immunotherapy.

Reproducibility and repeatability of six high-throughput 16S rDNA sequencing protocols for microbiota profiling

The paper evaluates six 16S rDNA sequencing protocols for microbiota profiling, finding that TS-tailed methods provide the highest reproducibility and repeatability on the HiSeq platform.