Author

T. Holyoak

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Research Focus:differential expression· 1 Research Focus:metabolism & bioenergetics· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

M. McLeod· 2 shared A. Ganesan· 1 shared B. Willard· 1 shared C. Hoppel· 1 shared D. Abbott· 1 shared D. Krokowski· 1 shared D. W. Moreau· 1 shared I. Bederman· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersBiochemistry

M. McLeod

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

The H163A Mutation Unravels an Oxidized Conformation of the SARS-CoV-2 Main Protease and Opens a New Avenue for Anti-Viral Therapeutic Design

N. Tran, S. Dasari, S. Barwell, M. McLeod, S. Kalyaanamoorthy, T. Holyoak, A. Ganesan

This study identifies an oxidized conformation of SARS-CoV-2 Mpro through a point mutation and suggests it could inform new antiviral strategies.

bioRxiv · Dec 16, 2022 · PreprintBiochemistry

Millisecond Mix-and-Quench Crystallography (MMQX) Enables Time-Resolved Studies of PEPCK With Remote Data Collection

J. A. Clinger, D. W. Moreau, M. J. McLeod, T. Holyoak, R. E. Thorne

This paper introduces MMQX, a method for time-resolved crystallography with millisecond resolution, demonstrating its use in studying PEPCK enzyme kinetics.

bioRxiv · Apr 6, 2021Biochemistry

Discovery of a redox-thiol switch regulating cellular energy metabolism

X.-H. Gao, L. Li, M. Parisien, M. Mcleod, J. Wu, I. Bederman, Z. Gao, D. Krokowski, S. M. Chirieleison, L. Diatchenko, D. Abbott, V. Yee, C. Hoppel, R. Kibbey, T. Holyoak, , M. Hatzoglou

The paper identifies a Redox Thiol Switch (RTSGS) that regulates cellular energy metabolism by switching between S-glutathionylation and S-sulfhydration, with PCK2 as a novel target.

bioRxiv · Jan 14, 2019 · PreprintBiochemistry