A. Ganesan

Improved prediction of stabilizing mutations in proteins by incorporation of mutational effects on ligand binding

The paper improves stabilizing mutation prediction by combining computational methods with experimental data, achieving higher precision and thermal stability increases.

The interferon/STAT1 signaling axis is a common feature of tumor-initiating cells in breast cancer

The paper identifies an IFN/STAT1 transcriptional state in tumor-initiating cells (TIC) of breast cancer using single-cell RNA sequencing, showing it differs from bulk RNA-seq derived TIC signatures.

The H163A Mutation Unravels an Oxidized Conformation of the SARS-CoV-2 Main Protease and Opens a New Avenue for Anti-Viral Therapeutic Design

This study identifies an oxidized conformation of SARS-CoV-2 Mpro through a point mutation and suggests it could inform new antiviral strategies.

Post-vaccination Omicron infections induce broader immunity across antigenic space than prototype mRNA COVID-19 booster vaccination or primary infection

The paper compares antibody responses to different SARS-CoV-2 variants after vaccination and infection, finding that post-vaccination Omicron infection induces broader immunity than triple vaccination alone.

Crosstalk of Histone Modifications in the Healthy Human Immune System

The paper analyzes histone post-translational modifications in human immune cells to uncover their interactions and functional implications.

SARS-CoV-2 Omicron neutralization by therapeutic antibodies, convalescent sera, and post-mRNA vaccine booster

A third dose of Pfizer/BioNTech vaccine significantly boosts Omicron neutralizing antibodies, while convalescent sera and therapeutic antibodies show variable and often low neutralization.

Durability of SARS-CoV-2-specific T cell responses at 12-months post-infection

This study examines SARS-CoV-2-specific T cell responses 12-months post-infection, finding durable responses with higher frequencies in those with severe acute illness.

Spatial transcriptomics using combinatorial fluorescence spectral and lifetime encoding, imaging and analysis

This paper introduces MOSAICA, a spatial transcriptomics technology that combines spectral and lifetime encoding with machine learning to enable highly multiplexed in situ biomarker profiling.

Molecular dynamics and in silico mutagenesis on the reversible inhibitor-bound SARS-CoV-2 Main Protease complexes reveal the role of lateral pocket in enhancing the ligand affinity

This study uses molecular dynamics simulations and in silico mutagenesis to analyze ligand binding in SARS-CoV-2 Mpro, identifying key residues and a lateral pocket critical for enhancing ligand affinity.

Signaling Diversity Enabled by Rap1-Regulated Plasma Membrane ERK with Distinct Temporal Dynamics

The paper shows EGF induces sustained plasma membrane ERK activity regulated by Rap1, distinct from transient cytoplasmic and nuclear ERK activity, highlighting spatial-temporal regulation in signaling specificity.