Single cell RNA-seq identifies inflammation-induced loss of CFTR-expressing airway ionocytes in non-eosinophilic asthma
L. Chen, G. A. Hoefel, P. S. Pathinayake, A. Reid, C. Kelly, T. HuiYing, R. Y. Kim, P. M. Hansbro, S. L. Brody, P. S. Foster, J. C. Horvat, C. Riveros, P. A. Wark, G. E. Kaiko
This study identifies inflammation-induced loss of CFTR-expressing ionocytes in non-eosinophilic asthma using single-cell RNA-seq and confirms it in human and murine models.
bioRxiv · Apr 26, 2022 · PreprintCell Biology