S. L. Brody

Loss of an extensive ciliary connectome induces proteostasis and cell fate switching in a severe motile ciliopathy

The paper identifies cellular defects beyond motility loss in ciliopathies caused by CCDC39/CCDC40 variants, showing proteostasis disruption and cell fate switching.

Ultrastructure expansion microscopy (U-ExM) of mouse and human kidneys for analysis of subcellular structures

This paper describes a U-ExM protocol for analyzing subcellular structures in mouse and human kidney tissues with high detail using conventional microscopy.

mTOR signaling regulates aberrant epithelial cell proliferative and migratory behaviors characteristic of airway mucous metaplasia in asthma

This study shows mTOR signaling drives aberrant epithelial behaviors in asthma, including proliferation and migration, and its inhibition reduces mucous metaplasia features.

A basally active cGAS-STING pathway limits SARS-CoV-2 replication in a subset of ACE2 positive airway cell models

This study identifies tonic activation of the cGAS-STING and IFN pathways in ACE2-positive airway cells as a factor limiting SARS-CoV-2 replication.

A potent MAPK13-14 inhibitor prevents airway inflammation and mucus production

This paper develops a potent MAPK13-14 inhibitor, NuP-3, which reduces airway inflammation and mucus production in human airway models and minipig disease models.

The effect of Dnaaf5 gene dosage on primary ciliary dyskinesia phenotypes

This study investigates the effects of Dnaaf5 gene dosage on primary ciliary dyskinesia phenotypes using mouse models, revealing allele-specific and tissue-specific molecular requirements for cilia motor assembly.

Single cell RNA-seq identifies inflammation-induced loss of CFTR-expressing airway ionocytes in non-eosinophilic asthma

This study identifies inflammation-induced loss of CFTR-expressing ionocytes in non-eosinophilic asthma using single-cell RNA-seq and confirms it in human and murine models.

Lung epithelial cell-derived C3 protects against pneumonia-induced lung injury

The paper shows lung-derived C3 reduces pneumonia-induced lung injury through the Factor B pathway, independent of circulating C3 levels.

Engineering Rotating Apical-Out Airway Organoid for Assessing Respiratory Cilia Motility

This study develops a rotating apical-out airway organoid model and computational framework to assess cilia motility and its defects in disease states.

Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell

This study identifies H522 cells as ACE2-negative human cells permissive to SARS-CoV-2 infection, revealing alternative receptor usage and host response mechanisms.

The translational landscape of SARS-CoV-2 and infected cells

This study uses ribosome profiling to analyze SARS-CoV-2 and host mRNA translation in infected cells, finding that viral mRNAs are not more efficiently translated than host mRNAs and highlighting unique translational strategies.

Mucin granules are degraded in the autophagosome-lysosome pathway as a means of resolving airway mucous cell metaplasia

This study shows that autophagy degrades mucin granules in airway mucous cells during resolution of mucous cell metaplasia, offering a therapeutic target for airway diseases.

Functional partitioning of a liquid-like organelle during assembly of axonemal dyneins

The paper shows that inner and outer dynein arm subunits are partitioned into non-overlapping regions within DynAPs and identifies Daap1 as a novel regulator of ODA deployment.

Chemokine receptor 2-targeted molecular imaging in pulmonary fibrosis

PET imaging of CCR2+ cells in lung fibrosis identifies therapeutic response in mouse models and shows perifibrotic signal in IPF patients.