Bridging the gap between in silico and in vivo: modeling opioid disposition in a kidney proximal tubule microphysiological system
T. Imaoka, W. Huang, S. Shum, D. W. Hailey, S.-Y. Chang, A. Chapron, C. K. Yeung, J. Himmelfarb, N. Isoherranen, E. J. Kelly
This study predicts opioid kidney clearance and systemic disposition in CKD patients using a microphysiological system and PBPK modeling.
bioRxiv · Dec 4, 2020Pharmacology & Toxicology