Author

J. Himmelfarb

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Cell Biology· 2 Cancer Biology· 1 Pharmacology & Toxicology· 1

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Approach:experimental assay· 5 Organism:human· 4 Assay:bulk RNA-seq· 3 Assay:ATAC-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Research Focus:differential expression· 2

Frequent Co-Authors

C. K. Yeung· 2 shared E. J. Kelly· 2 shared S. Akilesh· 2 shared Y. Zheng· 2 shared A. Aliseda· 1 shared A. B. Theberge· 1 shared A. Chapron· 1 shared A. Johnson· 1 shared

Activity by Year

2018-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersCell Biology

C. K. Yeung

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Author profile →

6 papers

Recent·Most cited

Immunomodulatory Porous Regenerative Scaffolds for in situ Vascular Engineering

L. Zhen, E. Quiroga, S. A. Creason, N. Chen, T. R. Sapre, J. M. Snyder, S. L. Lindhartsen, B. S. Fountaine, M. C. Barbour, S. Faisal, A. Aliseda, B. W. Johnson, J. Himmelfarb, B. D. Ratner

This study demonstrates that immunomodulatory porous scaffolds improve vascular graft healing by promoting endothelialization and transmural cellular infiltration compared to standard PTFE grafts.

Biomaterials · Sep 1, 2025Peer-reviewedBioengineering

Targeting an anchored phosphatase-deacetylase unit restores renal ciliary homeostasis.

J. Gopalan, M. Omar, A. Roy, N. M. Cruz, J. Falcone, K. Forbush, J. Himmelfarb, B. Freedman, J. D. Scott

The paper shows that targeting the AKAP220-PPI-HDAC6 pathway restores renal ciliary homeostasis in ADPKD models by modulating actin dynamics and cilia development.

bioRxiv · Feb 24, 2021Cell Biology

Multi-omic Characterization of Human Tubular Epithelial Cell Response to Serum

K. A. Lidberg, S. Muthusamy, M. Adil, R. S. Patel, L. Wang, T. K. Bammler, J. Reichel, C. K. Yeung, J. Himmelfarb, E. J. Kelly, S. Akilesh

The paper characterizes the transcriptional and epigenomic response of human tubular epithelial cells to serum exposure, identifying key regulatory programs and gene signatures.

bioRxiv · Jan 29, 2021Cell Biology

Bridging the gap between in silico and in vivo: modeling opioid disposition in a kidney proximal tubule microphysiological system

T. Imaoka, W. Huang, S. Shum, D. W. Hailey, S.-Y. Chang, A. Chapron, C. K. Yeung, J. Himmelfarb, N. Isoherranen, E. J. Kelly

This study predicts opioid kidney clearance and systemic disposition in CKD patients using a microphysiological system and PBPK modeling.

bioRxiv · Dec 4, 2020Pharmacology & Toxicology

Open microfluidic coculture reveals paracrine signaling from human kidney epithelial cells promotes kidney specificity of endothelial cells

T. Zhang, D. Lih, R. Nagao, J. Xue, E. Berthier, J. Himmelfarb, Y. Zheng, A. B. Theberge

This study uses an open microfluidic coculture system to show that human kidney epithelial cells promote kidney-specific gene expression in endothelial cells through paracrine signaling.

bioRxiv · Feb 14, 2020Bioengineering

Cryptic Promoter Activation Drives POU5F1 (OCT4) Expression in Renal Cell Carcinoma

K. T. Siebenthall, C. P. Miller, J. D. Vierstra, J. Mathieu, M. Tretiakova, A. Reynolds, R. Sandstrom, E. Rynes, S. J. Neph, E. Haugen, A. Johnson, J. Nelson, D. Bates, M. Diegel, D. Dunn, , S. Akilesh

The paper identifies a HIF-pathway-responsive cryptic promoter driving POU5F1 expression in RCC, linked to poor patient outcomes.

bioRxiv · Jul 27, 2018Cancer Biology