N. Isoherranen

Drugs Form Ternary Complexes with Human Liver Fatty Acid Binding Protein (FABP1) and FABP1 Binding Alters Drug Metabolism

This study shows drugs form ternary complexes with human FABP1 and that FABP1 binding alters drug metabolism by affecting CYP2C9 activity.

Discovery and visualization of uncharacterized drug-protein adducts using mass spectrometry.

The paper introduces Magnum, an algorithm for identifying drug-protein adducts, and Limelight, a tool for analyzing and visualizing adduct data, validated with CYP3A4 examples.

Bridging the gap between in silico and in vivo: modeling opioid disposition in a kidney proximal tubule microphysiological system

This study predicts opioid kidney clearance and systemic disposition in CKD patients using a microphysiological system and PBPK modeling.

Preclinical Modeling of Exposure to a Global Marine Bio Contaminant: Effects of In Utero Domoic Acid Exposure on Neonatal Behavior and Infant Memory

This study examines the effects of prenatal domoic acid exposure on neonatal behavior and memory in monkeys, finding impaired recognition memory at higher doses.

Chronic, Low-Level Oral Exposure to Marine Toxin, Domoic Acid, Alters Whole Brain Morphometry in Nonhuman Primates

This study examines the effects of chronic low-level domoic acid exposure on brain structure and chemistry in nonhuman primates, finding correlations between tremors and reduced fractional anisotropy and increased lactate levels.

Effects of Oral Domoic Acid Exposure on Maternal Reproduction and Infant Birth Characteristics in a Preclinical Nonhuman Primate Model

This study examines the effects of chronic low-dose domoic acid exposure on maternal reproduction and infant birth characteristics in nonhuman primates, finding no reproductive or physical developmental effects but subtle neurological effects in adult females.