Author

D. W. Hailey

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

A. Knupp· 2 shared J. E. Young· 2 shared M. Szabo· 2 shared S. Mishra· 2 shared A. Chapron· 1 shared C. A. Williams· 1 shared C. K. Yeung· 1 shared C. Kinoshita· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersCell Biology

A. Knupp

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Author profile →

3 papers

Recent·Most cited

The Alzheimer's gene SORL1 is a key regulator of endosomal traffic and recycling in human neurons

S. Mishra, A. Knupp, M. Szabo, C. A. Williams, C. Kinoshita, D. W. Hailey, Y. Wang, J. E. Young

This study shows SORL1 regulates endosomal recycling in neurons by affecting APP, TRKB, and GLUA1 trafficking, with implications for Alzheimer's disease.

bioRxiv · Jul 26, 2021Cell Biology

Bridging the gap between in silico and in vivo: modeling opioid disposition in a kidney proximal tubule microphysiological system

T. Imaoka, W. Huang, S. Shum, D. W. Hailey, S.-Y. Chang, A. Chapron, C. K. Yeung, J. Himmelfarb, N. Isoherranen, E. J. Kelly

This study predicts opioid kidney clearance and systemic disposition in CKD patients using a microphysiological system and PBPK modeling.

bioRxiv · Dec 4, 2020Pharmacology & Toxicology

Depletion of the AD risk gene SORL1 selectively impairs neuronal endosomal traffic independent of amyloidogenic APP processing

A. Knupp, S. Mishra, R. Martinez, J. Braggin, M. Szabo, D. W. Hailey, S. A. Small, S. Jayadev, J. E. Young

This study shows that SORL1 depletion in neurons causes endosome enlargement, a key AD hallmark, without affecting amyloidogenic APP processing.

bioRxiv · Jan 6, 2020Cell Biology