Mast cell-derived BH4 is a critical mediator of postoperative pain
P. Starkl, G. Jonsson, T. J. Artner, B. L. Turnes, N. Serhan, T. Oliveira, L.-M. Gail, K. Stejskal, K. Channon, T. Kocher, G. Stary, V. Klang, N. Gaudenzio, S. Knapp, C. J. Woolf, , S. J. F. Cronin
This study identifies mast cell-derived BH4 as a key mediator of postoperative pain, showing that substance P triggers BH4-dependent serotonin release in mast cells, and blocking substance P reduces pain.
bioRxiv · Jan 24, 2023 · PreprintImmunology