Author

G. Jonsson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5 Cell Biology· 2 Immunology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Organism:human· 7 Research Focus:cancer & tumor microenvironment· 4 Research Focus:cell type annotation· 4 Organism:mouse· 4 Research Focus:development & morphogenesis· 3 Research Focus:differential expression· 3 Research Focus:drug response / drug discovery· 3

Frequent Co-Authors

J. M. Penninger· 5 shared T. Oliveira· 3 shared A. Hagelkrueys· 2 shared A. Leopoldi· 2 shared D. Hoffmann· 2 shared M. Lauss· 2 shared S. Mereiter· 2 shared A. Azimi· 1 shared

Activity by Year

2019-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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5 shared papersCancer Biology

J. M. Penninger

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Author profile →

10 papers

Recent·Most cited

CLEC18A interacts with sulfated GAGs and controls clear cell renal cell carcinoma progression

G. Jonsson, M. Hofmann, S. Mereiter, L. Hartley-Tassell, I. Sakic, T. Oliveira, D. Hoffmann, M. Novatchkova, A. Schleiffer, J. M. Penninger

This study identifies CLEC18A as a regulator of clear cell renal cell carcinoma progression by interacting with sulfated GAGs and shows its expression is linked to improved patient survival.

bioRxiv · Jul 8, 2024Cancer Biology

An automated microfluidic platform integrating functional vascularized organoids-on-chip

C. Quintard, G. Jonsson, C. Laporte, C. Bissardon, A. Pitaval, N. Werschler, A. Leopoldi, A. Hagelkrüys, P. Blandin, J.-L. Achard, F. Navarro, Y. Fouillet, J. M. Penninger, X. Gidrol

This paper develops a microfluidic platform to create functional vascular networks around organoids, demonstrating perfusion within spheroids and vascular organoids over 15 days.

Nature Communications · Feb 16, 2024Peer-reviewedBioengineering

Tumor sialylation controls effective anti-cancer immunity in breast cancer

S. Mereiter, G. Jonsson, T. Oliveira, J. Helm, D. Hoffmann, M. Abeln, A.-K. Jochum, W. Jochum, M. J. Kellner, M. Feith, V. Tkalec, K. Wasilewska, J. Jiao, L. Emsenhuber, F. Holstein, , J. M. Penninger

This study shows that tumor sialylation suppresses anti-cancer immunity in breast cancer by altering immune cell interactions and checkpoint ligands, and that inhibiting sialylation enhances immune response and therapy effectiveness.

bioRxiv · Sep 20, 2023 · PreprintCancer Biology

Mast cell-derived BH4 is a critical mediator of postoperative pain

P. Starkl, G. Jonsson, T. J. Artner, B. L. Turnes, N. Serhan, T. Oliveira, L.-M. Gail, K. Stejskal, K. Channon, T. Kocher, G. Stary, V. Klang, N. Gaudenzio, S. Knapp, C. J. Woolf, , S. J. F. Cronin

This study identifies mast cell-derived BH4 as a key mediator of postoperative pain, showing that substance P triggers BH4-dependent serotonin release in mast cells, and blocking substance P reduces pain.

bioRxiv · Jan 24, 2023 · PreprintImmunology

NKG2D signaling regulates IL-17A-producing γδT cells to promote cancer progression

S. Curio, S. C. Edwards, T. Suzuki, J. McGovern, C. Triulzi, N. Yoshida, G. Jonsson, T. Glauner, D. Rami, R. Purcell, S. B. Coffelt, N. Guerra

This study shows that NKG2D signaling promotes IL-17A-producing γδT cells, which drive cancer progression in intestinal tumors.

bioRxiv · Aug 26, 2021 · PreprintImmunology

A diabetic milieu increases cellular susceptibility to SARS-CoV-2 infections in engineered human kidney organoids and diabetic patients

E. Garreta, P. Prado, M. L. Stanifer, V. Monteil, C. Hurtado del Pozo, A. Ullate-Agote, A. Vilas-Zornoza, J. P. Romero, G. Jonsson, R. Oria, A. Leopoldi, A. Hagelkrueys, D. Moya-Rull, F. Gonzalez, A. Marco, , N. Montserrat

This study shows that a diabetic environment increases SARS-CoV-2 susceptibility in kidney organoids and patients by upregulating ACE2, which is critical for viral replication.

bioRxiv · Aug 13, 2021 · PreprintCell Biology

The ubiquitin ligase HOIL-1L regulates immune responses by interacting with linear ubiquitin chains

C. Gomez Diaz, G. Jonsson, K. Schodl, L. Deszcz, A. Bestehorn, K. Eislmayr, J. Almagro, A. Kavirayani, L. M. Fennell, A. Hagelkrueys, P. Kovarik, J. M. Penninger, F. Ikeda

This study shows that the HOIL-1L NZF domain regulates immune responses by binding linear ubiquitin chains, affecting TNF and LPS-induced inflammation in mice.

bioRxiv · Apr 13, 2021Cell Biology

BRN2 is a non-canonical melanoma tumor-suppressor

M. Hamm, P. Sohier, V. Petit, J. Raymond, V. Delmas, M. Le Coz, F. Gesbert, C. Kenny, Z. Aktary, M. Pouteaux, F. Rambow, A. Sarasin, A. Bellacosa, L. Sanchez-del-Campo, L. Mosteo, , L. Larue

This study identifies BRN2 as a non-canonical tumor suppressor in melanoma, showing its role in initiation and progression through PTEN regulation and PI3K signaling.

bioRxiv · Jan 13, 2021Cancer Biology

PTENP1-AS contributes to BRAF inhibitor resistance and is associated with adverse clinical outcome in stage III melanoma

L. Vidarsdottir, A. Azimi, I. Sigvaldadottir, A. S. Rahmanto, A. Petri, S. Kauppinen, C. Ingvar, G. Jonsson, H. Olsson, M. Frostvik-Stolt, R. Tuominen, O. Sangfelt, K. Pokrovskaja, J. Hansson, D. Grander, , P. Johnsson

This study shows that PTENP1-AS contributes to BRAF inhibitor resistance and is linked to poor clinical outcomes in stage III melanoma.

bioRxiv · May 3, 2020Cancer Biology

Escape from nonsense mediated decay associates with anti-tumor immunogenicity

K. Litchfield, J. Reading, E. Lim, H. Xu, P. Liu, M. Al-Bakir, S. Wong, A. Rowan, S. Funt, T. Merghoub, M. Lauss, I. M. Svane, G. Jonsson, J. Herrero, J. Larkin, , C. Swanton

This study identifies NMD-escape fs-indels as a biomarker associated with improved response to immunotherapy in melanoma patients.

bioRxiv · Nov 14, 2019Cancer Biology