Author

J. A. Cole

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:E. coli· 3 Organism:bacteria (other)· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1

Frequent Co-Authors

I. R. Henderson· 5 shared A. F. Cunningham· 4 shared J. A. Bryant· 4 shared C. Icke· 3 shared E. C. A. Goodall· 2 shared J. Gray· 2 shared K. Pullela· 2 shared S. A. McKeand· 2 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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5 shared papersMicrobiology

I. R. Henderson

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Author profile →

6 papers

Recent·Most cited

Inhibition of Neisseria gonorrhoeae complement-mediated killing during acute gonorrhoea is dependent upon the IgG2:IgG3 antibody ratio

S. A. McKeand, S. E. Faustini, A. Cook, N. Kennett, M. T. Drayson, A. F. Cunningham, I. R. Henderson, J. D. C. Ross, J. A. Cole, A. E. Rossiter-Pearson

The paper identifies that a high IgG2:IgG3 antibody ratio inhibits complement-mediated killing of Neisseria gonorrhoeae, revealing a mechanism for bacterial resistance.

bioRxiv · Sep 26, 2023 · PreprintMicrobiology

Genome-wide synthetic-lethality screen of Bam complex associated genes in Escherichia coli

J. A. Bryant, K. A. Staunton, H. M. Doherty, M. B. Alao, X. Ma, J. Morcinek-Orlowska, E. C. A. Goodall, J. Gray, M. Milner, L. Kidger, C. D. Neilson, J. A. Cole, F. de Cogan, T. J. Knowles, M. K. Glinkowska, , M. Banzhaf

The paper identifies synthetic-lethal interactions of Bam complex associated genes in E. coli, revealing dependencies on lipid composition and peptidoglycan synthesis.

bioRxiv · Jul 5, 2023Microbiology

Transposon mutagenesis screen in Klebsiella pneumoniae identifies genetic determinants required for growth in human urine and serum

J. Gray, V. V. L. Torres, E. C. Goodall, S. A. McKeand, D. Scales, C. Collins, L. Wetherall, Z. J. Lian, J. A. Bryant, M. T. Milner, K. Dunne, C. Icke, J. Rooke, T. Schneiders, P. A. Lund, , I. R. Henderson

This study identifies essential genes for Klebsiella pneumoniae growth in human urine and serum using transposon mutagenesis, highlighting potential antimicrobial targets.

bioRxiv · May 31, 2023Microbiology

YhcB coordinates peptidoglycan and LPS biogenesis with phospholipid synthesis during Escherichia coli cell growth.

E. C. A. Goodall, G. L. Isom, J. L. Rooke, C. Icke, K. Pullela, B. Zhang, J. Rae, W. B. Tan, M. Winkle, A. Delhaye, E. Heinz, J.-F. Collet, A. F. Cunningham, M. A. Blaskovich, R. G. Parton, , I. R. Henderson

This study identifies YhcB as a coordinator of peptidoglycan, LPS, and phospholipid synthesis in E. coli, revealing its role in envelope stability and cell size control.

bioRxiv · Apr 16, 2021Microbiology

Glycine acylation and trafficking of a new class of bacterial lipoprotein by a composite secretion system

C. Icke, F. Hodges, K. Pullela, S. McKeand, J. A. Bryant, A. F. Cunningham, J. A. Cole, I. R. Henderson

The paper identifies a new bacterial secretion system, Aat, that acylates a lipoprotein, CexE, on a glycine residue instead of the typical cysteine, leading to surface display of the protein.

bioRxiv · Sep 23, 2020Microbiology

Characterization of emetic and diarrheal Bacillus cereus strains from a 2016 foodborne outbreak using whole-genome sequencing: addressing the microbiological, epidemiological, and bioinformatic challenges

L. M. Carroll, M. Wiedmann, M. Mukherjee, D. C. Nicholas, L. A. Mingle, N. B. Dumas, J. A. Cole, J. Kovac

This paper uses whole-genome sequencing to characterize B. cereus group strains from a foodborne outbreak, identifying emetic and diarrheal isolates and their genetic relationships.

bioRxiv · Aug 24, 2018Microbiology