Author

T. J. McCorvie

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:protein folding & dynamics· 3 Assay:structural biology· 2 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

W. W. Yue· 3 shared A. Basle· 2 shared D. S. Froese· 2 shared A. P. Berg· 1 shared C. Burer· 1 shared C. Strain-Damerell· 1 shared H. J. Bailey· 1 shared I. M. Ferreira· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersBiochemistry

W. W. Yue

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Author profile →

3 papers

Recent·Most cited

Dynamic inter-domain transformations mediate the allosteric regulation of human 5, 10-methylenetetrahydrofolate reductase

L. K. M. Blomgren, M. Huber, S. R. Mackinnon, C. Burer, A. Basle, W. W. Yue, D. S. Froese, T. J. McCorvie

The paper determines cryo-EM structures of human MTHFR bound to SAM and SAH, revealing how inter-domain transformations mediate allosteric regulation by altering active site accessibility.

bioRxiv · Aug 2, 2023Biochemistry

Architecture and regulation of filamentous humancystathionine beta-synthase

T. J. McCorvie, H. J. Bailey, C. Strain-Damerell, A. Basle, W. W. Yue

This study uses cryo-electron microscopy to reveal how human CBS regulates activity through conformational changes in its regulatory domain.

bioRxiv · Feb 15, 2023Biochemistry

Molecular basis for the regulation of human glycogen synthase by phosphorylation and glucose-6-phosphate

T. J. McCorvie, P. M. Loria, M. Tu, S. Han, L. Shrestha, D. S. Froese, I. M. Ferreira, A. P. Berg, W. W. Yue

This study presents cryo-EM structures of phosphorylated human GYS1 complexed with GYG1, revealing how phosphorylation and glucose-6-phosphate regulate glycogen synthase activity.

bioRxiv · Nov 12, 2021Biochemistry