Author

D. S. Froese

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 5 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 5 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:protein folding & dynamics· 2 Research Focus:protein structure prediction· 2 Assay:structural biology· 2 Assay:cryo-EM· 1

Frequent Co-Authors

W. W. Yue· 4 shared M. R. Baumgartner· 3 shared S. Lutz· 2 shared T. J. McCorvie· 2 shared T. Suormala· 2 shared A. Basle· 1 shared A. Chaikuad· 1 shared A. Kaech· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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4 shared papersBiochemistry

W. W. Yue

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Author profile →

6 papers

Recent·Most cited

Dynamic inter-domain transformations mediate the allosteric regulation of human 5, 10-methylenetetrahydrofolate reductase

L. K. M. Blomgren, M. Huber, S. R. Mackinnon, C. Burer, A. Basle, W. W. Yue, D. S. Froese, T. J. McCorvie

The paper determines cryo-EM structures of human MTHFR bound to SAM and SAH, revealing how inter-domain transformations mediate allosteric regulation by altering active site accessibility.

bioRxiv · Aug 2, 2023Biochemistry

Insights into energy balance dysregulation from a mouse model of methylmalonic aciduria

M. Lucienne, R. Gerlini, B. Rathkolb, J. Calzada-Wack, P. Forny, S. Wüest, A. Kaech, F. Traversi, M. Forny, C. Bürer, J. A. Aguilar-Pimentel, M. Irmler, J. Beckers, S. Sauer, S. Kölker, , M. Hrabe de Angelis

This study examines a mouse model of methylmalonic aciduria, finding reduced energy expenditure, altered metabolism, and metabolic inflexibility.

bioRxiv · Nov 30, 2021Physiology

Molecular basis for the regulation of human glycogen synthase by phosphorylation and glucose-6-phosphate

T. J. McCorvie, P. M. Loria, M. Tu, S. Han, L. Shrestha, D. S. Froese, I. M. Ferreira, A. P. Berg, W. W. Yue

This study presents cryo-EM structures of phosphorylated human GYS1 complexed with GYG1, revealing how phosphorylation and glucose-6-phosphate regulate glycogen synthase activity.

bioRxiv · Nov 12, 2021Biochemistry

Naturally occurring cobalamin (B12) analogs can function as cofactors for human methylmalonyl-CoA mutase

O. M. Sokolovskaya, T. Plessl, H. Bailey, S. Mackinnon, M. R. Baumgartner, W. W. Yue, D. S. Froese, M. E. Taga

The paper investigates how different cobamides affect the function of methylmalonyl-CoA mutase and shows that non-cobalamin cobamides can also support its activity.

bioRxiv · Mar 20, 2020Biochemistry

Genetic, structural, and functional analysis of mutations causing methylmalonyl-CoA epimerase deficiency

K. Heuberger, H. J. Bailey, P. Burda, A. Chaikuad, E. Krysztofinska, T. Suormala, C. Buerer, S. Lutz, B. Fowler, D. S. Froese, W. W. Yue, M. R. Baumgartner

The paper identifies ten new patients with MCEE deficiency, analyzes mutations in the MCEE gene, and reveals structural and functional defects in the enzyme caused by these mutations.

bioRxiv · Nov 30, 2018Biochemistry

Structural basis of human 5,10-methylenetetrahydrofolate reductase (MTHFR) regulation by phosphorylation and S-adenosylmethionine inhibition

D. S. Froese, J. Kopec, E. Rembeza, G. A. Bezerra, A. Oberholzer, T. Suormala, S. Lutz, R. Chalk, O. Borkowska, M. Baumgartner, W. Yue

This study presents the 2.5 Å resolution crystal structure of human MTHFR, revealing its architecture and how phosphorylation and SAM binding regulate its activity.

bioRxiv · Feb 26, 2018Biochemistry