Author

T. Juhel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

P. Hofman· 3 shared S. Janho dit Hreich· 2 shared V. Vouret-Craviari· 2 shared A. Ghinet· 1 shared A. Hubstenberger· 1 shared B. Mari· 1 shared B. Mograbi· 1 shared B. Romeo· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersCancer Biology

P. Hofman

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Author profile →

3 papers

Recent·Most cited

Activation of the P2RX7/IL-18 pathway in immune cells attenuates lung fibrosis

S. Janho dit Hreich, T. Juhel, S. Leroy, F. Brau, V. Hofman, P. Hofman, V. Vouret-Craviari

This study shows that activating the P2RX7/IL-18 pathway in immune cells reduces lung fibrosis in a mouse model by promoting an anti-fibrotic immune environment.

bioRxiv · Dec 15, 2022Immunology

Processing body dynamics drive non-genetic MEK inhibitors tolerance by fine-tuning KRAS and NRAS translation

O. Vidal-Cruchez, V. J. Nicolini, T. Rete, R. Rezzonico, C. Lacoux, J. Fassy, K. Jacquet, M. A. Domdom, C. Ventujol, T. Juhel, B. Romeo, J. Roux, A. Hubstenberger, B. Mari, B. Mograbi, , P. Brest

The paper identifies a mechanism where MEK inhibitors induce tolerance by promoting KRAS and NRAS translation via PB dissolution, revealing a dynamic feedback loop in MAPK signaling.

bioRxiv · Dec 6, 2021 · PreprintCancer Biology

Small-molecule P2RX7 activator sensitizes tumor to immunotherapy and vaccinates mouse against tumor re-challenge

L. Douguet, S. Janho dit hreich, J. Benzaquen, l. seguin, T. Juhel, X. Dezitter, C. Duranton, B. Ryffel, J. Kanellopoulos, C. Delarasse, N. Renault, C. Furman, G. Homerin, C. Feral, J. Cherfils-Vicini, , V. Vouret-Craviari

The paper develops a P2RX7 activator that enhances immunotherapy efficacy and provides long-term tumor protection in mice.

bioRxiv · Nov 19, 2020 · PreprintCancer Biology