Author

P. Hofman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Immunology· 2 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:drug response / drug discovery· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:proteomics· 2

Frequent Co-Authors

T. Juhel· 3 shared V. Hofman· 3 shared B. Mari· 2 shared J. Cherfils-Vicini· 2 shared J. Fassy· 2 shared L. Seguin· 2 shared M.-C. Michallet· 2 shared R. Rezzonico· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersCancer Biology

T. Juhel

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Aging affects reprogramming of murine pulmonary capillary endothelial cells after lung injury

M. Truchi, M. Gautier-Isola, G. Savary, H. Cadis, C. Scribe, A. Baeri, A. Lingampally, V. Magnone, C. Girard-Riboulleau, M.-J. Arguel, C. de Schutter, J. Fassy, N. Boukrout, R. Larrue, N. Martin, , B. Mari

This study compares transcriptomic changes in pulmonary capillary endothelial cells from young and aged mice after lung injury, finding age-related differences in resolution and fibrotic signatures.

bioRxiv · Jul 11, 2023 · PreprintPathology

Activation of the P2RX7/IL-18 pathway in immune cells attenuates lung fibrosis

S. Janho dit Hreich, T. Juhel, S. Leroy, F. Brau, V. Hofman, P. Hofman, V. Vouret-Craviari

This study shows that activating the P2RX7/IL-18 pathway in immune cells reduces lung fibrosis in a mouse model by promoting an anti-fibrotic immune environment.

bioRxiv · Dec 15, 2022Immunology

Processing body dynamics drive non-genetic MEK inhibitors tolerance by fine-tuning KRAS and NRAS translation

O. Vidal-Cruchez, V. J. Nicolini, T. Rete, R. Rezzonico, C. Lacoux, J. Fassy, K. Jacquet, M. A. Domdom, C. Ventujol, T. Juhel, B. Romeo, J. Roux, A. Hubstenberger, B. Mari, B. Mograbi, , P. Brest

The paper identifies a mechanism where MEK inhibitors induce tolerance by promoting KRAS and NRAS translation via PB dissolution, revealing a dynamic feedback loop in MAPK signaling.

bioRxiv · Dec 6, 2021 · PreprintCancer Biology

Disentangling heterogeneity of Malignant Pleural Mesothelioma through deep integrative omics analyses

L. Mangiante, N. Alcala, A. Di Genova, A. Sexton-Oates, A. Gonzalez-Perez, A. Khandekar, E. Bergstrom, J. Kim, C. Giacobi, N. Le-Stang, S. Boyault, C. Cuenin, S. Tabone-Eglinger, F. Damiola, C. Voegele, , Meyer

This study identifies four sources of heterogeneity in MPM using multi-omic factor analysis, showing how genomic events shape molecular profiles and clinical behavior.

bioRxiv · Sep 27, 2021Cancer Biology

A ganglioside-based senescence-associated immune checkpoint

C. Iltis, L. Seguin, L. Cervera, L. Duret, T. Hamidouch, S. Kunz, O. Croce, C. Delannoy, Y. Guerardel, F. Allain, L. Moudombi, P. Hofman, E. Cosson, J. Guglielmi, T. Pourcher, , J. Cherfils-Vicini

This paper identifies GD3 as a senescence-associated immune checkpoint that suppresses NK cell-mediated clearance of senescent cells, showing that targeting GD3 can enhance anti-fibrotic effects in a mouse model.

bioRxiv · Apr 23, 2021 · PreprintImmunology

Small-molecule P2RX7 activator sensitizes tumor to immunotherapy and vaccinates mouse against tumor re-challenge

L. Douguet, S. Janho dit hreich, J. Benzaquen, l. seguin, T. Juhel, X. Dezitter, C. Duranton, B. Ryffel, J. Kanellopoulos, C. Delarasse, N. Renault, C. Furman, G. Homerin, C. Feral, J. Cherfils-Vicini, , V. Vouret-Craviari

The paper develops a P2RX7 activator that enhances immunotherapy efficacy and provides long-term tumor protection in mice.

bioRxiv · Nov 19, 2020 · PreprintCancer Biology