J. Roux

Distinct circulating monocytes up-regulate CD52 and sustain innate immune function in patients with cirrhosis unless acute decompensation emerges

The paper identifies CD52-expressing monocytes in cirrhosis that enhance innate immunity, but their loss during acute decompensation correlates with infection and poor outcomes.

Targeting the expansion of myeloid-derived suppressor cells in liver cirrhosis

This study investigates MDSC expansion in cirrhosis patients and murine models, showing poly(I:C) reduces MDSC and fibrosis in infected fibrotic mice.

Multidimensional analysis of matched primary and recurrent glioblastoma identifies Fcgamma receptors upregulation on microglia as a contributor of tumor recurrence.

This study identifies Fcgamma receptor upregulation on activated microglia in recurrent glioblastoma as a factor associated with shorter time-to-relapse.

The Siglec-sialic acid-axis is a target for innate immunotherapy of glioblastoma

This study identifies the Siglec-sialic acid-axis as a target for innate immunotherapy in glioblastoma, showing that blocking Siglec-E enhances phagocytosis and T cell priming, leading to delayed tumor growth and prolonged survival.

Single-cell characterization of human GBM reveals regional differences in tumor-infiltrating leukocyte activation

The paper uses single-cell RNA sequencing to analyze regional differences in tumor-infiltrating leukocytes in GBM, revealing distinct transcriptional profiles and impaired activation states.

Processing body dynamics drive non-genetic MEK inhibitors tolerance by fine-tuning KRAS and NRAS translation

The paper identifies a mechanism where MEK inhibitors induce tolerance by promoting KRAS and NRAS translation via PB dissolution, revealing a dynamic feedback loop in MAPK signaling.

The Endocytic Recycling Compartment Serves as a Viral Factory for Hepatitis E Virus

This study identifies the endocytic recycling compartment as a site where HEV forms membrane networks, revealing a novel viral factory structure.

T cell stimulation remodels the latently HIV-1 infected cell population by differential activation of proviral chromatin

This study uses a single-cell method to assess HIV-1 proviral chromatin activation and shows that T cell stimulation differentially activates proviruses based on their chromatin state.

Epithelial GPR35 protects from Citrobacter rodentium infection by preserving goblet cells and mucosal barrier integrity

This study shows that epithelial Gpr35 maintains goblet cell function and mucosal barrier integrity, protecting against Citrobacter rodentium infection.

The non-coding RNA miR-17~92 is a central mediator of T cell activation

This study identifies miR-17~92 as a central mediator of T cell activation by enhancing the calcineurin/NFAT pathway and repressing negative regulators of activation.

In vitro culture of aberrant basal-like cells from fibrotic lung tissue

The paper cultures and characterizes aberrant basal-like cells from fibrotic lung tissue, finding they co-express epithelial and mesenchymal markers and show disease-specific transcriptomic differences between IPF and other ILD patients.

Air pollution mediates diabetes by disrupting gut innate mucosal immunity

This study shows air pollution causes diabetes by disrupting gut macrophage function, leading to beta-cell dysfunction through cytokine secretion.

Protection of bona fide T follicular memory cells during tissue isolation reveals their persistence, plasticity and functional impact

This study identifies TFH memory cells as distinct from TCM cells, showing their persistence, plasticity, and functional role in antibody production.

Genomic signatures accompanying the dietary shift to phytophagy in polyphagan beetles

This study identifies adaptive gene family expansions in polyphagan beetles associated with their shift to plant-feeding, supporting the role of plant chemical defenses in beetle diversification.

Selective constraints on coding sequences of nervous system genes are a major determinant of duplicate gene retention in vertebrates

The paper shows that nervous system gene duplicates are more likely to be retained after whole-genome duplication due to selective constraints on their coding sequences.