J. P. de Magalhaes

This study identifies rilmenidine as a caloric restriction mimetic that extends lifespan in C. elegans by activating the I1-imidazoline receptor and modulating pathways involved in stress resistance and autophagy.

This study analyzes age-related genomic, transcriptomic, and epigenetic changes across cancers using TCGA data, finding increased genomic instability and mutations in older patients.

This study identifies positive selection and gene duplications in tumour suppressor genes in cetaceans, linking them to cancer resistance, gigantism, and longevity.

This study compares age-related and cancer gene expression changes across nine human tissues, finding opposing trends and highlighting the role of cellular senescence in ageing and its potential to hinder cancer.