Author

C. Chaguza

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 4

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 3 Approach:statistical model· 3 Assay:whole-genome sequencing· 3 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

S. D. Bentley· 2 shared A. Alisoltani· 1 shared A. E. Green· 1 shared A. Iranzadeh· 1 shared A. K. Pöntinen· 1 shared A. Kalizang'oma· 1 shared A. Kamng'ona· 1 shared A. Kiran· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersMicrobiology

S. D. Bentley

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Expansion of pneumococcal serotype 23F and 14 lineages with genotypic changes in capsule polysaccharide locus and virulence gene profiles post introduction of pneumococcal conjugate vaccine in Blantyre, Malawi

R. Cave, A. Kalizang'oma, C. Chaguza, T. S. Mwalukomo, A. Kamng'ona, C. Brown, J. Msefula, F. Bonomali, R. Nyirenda, T. D. Swarthout, B. Kwambana-Adams, N. French, R. S. Heyderman

The paper analyzes whole-genome sequences of pneumococcal isolates in Malawi to show expansion of vaccine serotype lineages with genetic changes in capsule and virulence genes post-PCV13 introduction.

bioRxiv · Mar 25, 2024Microbiology

Pan-genome study underlining the extent of genomic variation of invasive Streptococcus pneumoniae in Malawi

A. Iranzadeh, A. Alisoltani, A. Kiran, R. Breiman, C. Chaguza, C. Peno, J. E. Cornick, D. B. Everett, N. Mulder

This study identifies serotypes 1 and 5 of Streptococcus pneumoniae as highly invasive in Malawi, showing genetic differences linked to shorter colonization and potential invasiveness.

bioRxiv · Jan 2, 2023 · PreprintMicrobiology

The population-level impact of Enterococcus faecalis genetics on intestinal colonisation and extraintestinal infection

C. Chaguza, A. K. Pöntinen, J. Top, S. Arredondo-Alonso, A. R. Freitas, C. Novais, C. Torres, S. D. Bentley, L. Peixe, T. M. Coque, R. J. L. Willems, J. Corander

This study investigates the genetic factors influencing E. faecalis intestinal colonization and extraintestinal infection using GWAS and heritability analysis across 750 isolates.

bioRxiv · Sep 26, 2022 · PreprintMicrobiology

Identification of colonisation and virulence determinants of Streptococcus pneumoniae via experimental evolution in mouse infection models

A. E. Green, D. Howarth, C. Chaguza, H. Echlin, R. F. Langendonk, C. Munro, T. E. Barton, J. C. Hinton, S. D. Bentley, J. Rosch, D. R. Neill

This study uses experimental evolution in mouse models to identify genetic factors affecting Streptococcus pneumoniae colonization and virulence.

bioRxiv · Sep 8, 2020 · PreprintMicrobiology