Author

J. Cursons

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:bulk RNA-seq· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

N. D. Huntington· 4 shared M. Foroutan· 3 shared C. Behrenbruch· 2 shared A. Anderson· 1 shared A. Behren· 1 shared A. G. Heriot· 1 shared A. I. Webb· 1 shared A. Kallies· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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4 shared papersCancer Biology

N. D. Huntington

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Author profile →

4 papers

Recent·Most cited

Targeting of TP53-independent cell cycle checkpoints overcomes FOLFOX resistance in Metastatic Colorectal Cancer

C. Behrenbruch, M. Foroutan, P. Lind, J. Smith, M. Grandin, B. Cooper, C. Shembrey, S. Ramm, K. Cowley, I. Nikolic, J. Liuu, J. Cursons, R. Millen, A.-M. Patch, N. D. Huntington, , F. Hollande

This study identifies FOLFOX resistance in metastatic CRC through cell cycle checkpoint dysregulation and shows that targeting these checkpoints can resensitize resistant organoids to FOLFOX.

bioRxiv · Feb 4, 2021 · PreprintCancer Biology

The ratio of exhausted to resident infiltrating lymphocytes is prognostic for colorectal cancer patient outcome

M. Foroutan, R. Molania, A. Pfefferle, C. Behrenbruch, A. Kallies, T. P. Speed, J. Cursons, N. D. Huntington

This study identifies signatures of lymphocyte residency and exhaustion in colorectal cancer using single-cell RNA-seq and shows their association with patient survival outcomes.

bioRxiv · Dec 19, 2020Cancer Biology

Therapeutic blockade of Activin-A improves NK cell function and anti-tumor immunity

J. Rautela, L. F. Dagley, I. S. Schuster, S. Hediyeh-Zadeh, R. Delconte, J. Cursons, R. Hennessy, D. S. Hutchinson, C. Harrison, C. C. Oliveira, E. Vivier, A. I. Webb, M. Degli-Esposti, M. Davis, N. D. Huntington, F. Souza-Fonseca-Guimaraes

This study shows Activin-A inhibits NK cell function, promotes transdifferentiation into ILC1-like cells, and suppresses anti-tumor immunity, with therapeutic blockade improving outcomes.

bioRxiv · Oct 29, 2018 · PreprintImmunology

A natural killer cell gene signature predicts melanoma patient survival

J. Cursons, F. Souza Fonseca Guimaraes, A. Anderson, M. Foroutan, S. Hediyeh Zadeh, A. Behren, N. D. Huntington, M. J. Davis

The paper develops an NK cell gene signature to predict survival in metastatic cutaneous melanoma patients using TCGA RNA-seq data.

bioRxiv · Aug 13, 2018 · PreprintCancer Biology