Author

M. L. Wang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Approach:genetic perturbation / CRISPR· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Guna· 2 shared R. M. Voorhees· 2 shared T.-F. Chou· 2 shared A. J. Inglis· 1 shared A. N. Pogson· 1 shared B. Lomenick· 1 shared C.-I. Chung· 1 shared D. Lu· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCell Biology

A. Guna

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Author profile →

3 papers

Recent·Most cited

Role of a holo-insertase complex in the biogenesis of biophysically diverse ER membrane proteins

K. R. Page, V. N. Nguyen, T. Pleiner, G. P. Tomaleri, M. L. Wang, A. Guna, T.-Y. Wang, T.-F. Chou, R. M. Voorhees

The paper studies the biogenesis of ER membrane proteins, identifying the EMC and BOS complex as key players and proposing a model for coordinated insertion.

bioRxiv · Nov 28, 2023Cell Biology

MTCH2 is a mitochondrial outer membrane protein insertase

A. Guna, T. A. Stevens, A. J. Inglis, J. M. Replogle, T. K. Esantsi, G. Muthukumar, K. C. L. Shaffer, M. L. Wang, A. N. Pogson, J. J. Jones, B. Lomenick, T.-F. Chou, J. S. Weissman, R. M. Voorhees

The paper identifies MTCH2 as an insertase required for mitochondrial TA protein insertion and shows its role in controlling TA localization and apoptosis sensitivity.

bioRxiv · Sep 15, 2022Cell Biology

Enhancing Intracellular Accumulation and Target Engagement of PROTACs with Reversible Covalent Chemistry

W.-H. Guo, X. Qi, X. Yu, Y. Liu, C.-I. Chung, F. Bai, X. Lin, D. Lu, L. Wang, J. Chen, L. Su, K. J. Nomie, F. Li, M. C. Wang, X. Shu, , J. Wang

This study discovers that reversible covalent chemistry enhances PROTAC intracellular accumulation and target engagement, leading to improved efficacy.

bioRxiv · Dec 30, 2019Pharmacology & Toxicology