Author

T. R. Jackson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Assay:fluorescence / live-cell microscopy· 1

Frequent Co-Authors

P. Vyas· 3 shared A. Russell· 2 shared D. Zhang· 2 shared G. M. Wynne· 2 shared K. S. Madden· 2 shared L. Josa-Cullere· 2 shared S. G. Davies· 2 shared T. J. Cogswell· 2 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersCancer Biology

P. Vyas

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Author profile →

4 papers

Recent·Most cited

HDAC inhibitor derivatives induce differentiation of leukemic cells through two distinct and separable mechanisms

P. Kumar, L. Josa-Cullere, T. R. Jackson, C. J. R. Bataille, P. Vyas, T. A. Milne, A. J. Russell

The paper shows HDAC inhibitors induce AML cell differentiation via two distinct mechanisms: one through G1 arrest and another through G2 arrest via Aurora A and GSK3 inhibition.

bioRxiv · Jan 6, 2024 · PreprintPharmacology & Toxicology

High-throughput widefield fluorescence imaging of 3D samples using deep learning for 2D projection image restoration

E. Forsgren, C. Edlund, M. Oliver, K. Barnes, R. Sjögren, T. R. Jackson

This paper combines axial z-sweep imaging with deep learning to restore high-quality 2D projections of 3D biological samples, enabling high-throughput and quantitative analysis.

bioRxiv · Feb 7, 2022Cell Biology

A novel tubulin binding molecule drives differentiation of acute myeloid leukaemia cells

T. R. Jackson, A. Vuorinen, L. Josa-Cullere, K. S. Madden, D. Conole, T. J. Cogswell, I. V. L. Wilkinson, L. M. Kettyle, D. Zhang, A. O'Mahony, D. Gracias, L. McCall, R. Westwood, G. C. Terstappen, S. G. Davies, , T. Milne

The paper identifies a novel tubulin-binding molecule that induces differentiation in AML cells, reducing tumour burden and improving survival in vivo.

bioRxiv · Jun 3, 2021 · PreprintCancer Biology

A phenotypic screen identifies a compound series that induces differentiation of acute myeloid leukemia cells in vitro and shows anti-tumour effects in vivo

L. Jose-Cullere, K. S. Madden, T. J. Cogswell, T. R. Jackson, T. S. Carter, D. Zhang, G. Trevitt, S. G. Davies, P. Vyas, G. M. Wynne, T. Milne, A. Russell

bioRxiv · Dec 18, 2020 · PreprintCancer Biology