Author

T. A. Milne

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Cancer Biology· 1 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Assay:CRISPR screen· 1

Frequent Co-Authors

A. E. Armitage· 1 shared A. E. Preston· 1 shared A. J. Mead· 1 shared A. J. Russell· 1 shared A. L. Smith· 1 shared A. Roy· 1 shared B. Kronsteiner· 1 shared B. P. Marzullo· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperImmunology

A. E. Armitage

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Author profile →

4 papers

Recent·Most cited

Iron deficiency causes aspartate-sensitive metabolic and proliferative dysfunction in CD8+ T cells

M. R. Teh, N. Gudgeon, J. N. Frost, L. V. Sinclair, A. L. Smith, C. L. Millington, B. Kronsteiner, J. Roberts, B. P. Marzullo, A. E. Preston, J. Rehwinkel, T. A. Milne, D. A. Tennant, S. J. Dunachie, A. E. Armitage, , H. Drakesmith

This study shows iron deficiency impairs CD8+ T cell proliferation and metabolism by disrupting mitochondrial function, but exogenous aspartate can rescue this defect.

bioRxiv · Feb 1, 2024 · PreprintImmunology

HDAC inhibitor derivatives induce differentiation of leukemic cells through two distinct and separable mechanisms

P. Kumar, L. Josa-Cullere, T. R. Jackson, C. J. R. Bataille, P. Vyas, T. A. Milne, A. J. Russell

The paper shows HDAC inhibitors induce AML cell differentiation via two distinct mechanisms: one through G1 arrest and another through G2 arrest via Aurora A and GSK3 inhibition.

bioRxiv · Jan 6, 2024 · PreprintPharmacology & Toxicology

A novel human fetal liver-derived model reveals that MLL-AF4 drives a distinct fetal gene expression program in infant ALL

S. Rice, T. Jackson, N. T. Crump, N. Fordham, N. Elliott, S. O Byrne, S. Inglott, D. Ladon, G. Wright, J. Bartram, P. Ancliff, A. J. Mead, C. Halsey, I. Roberts, T. A. Milne, A. Roy

bioRxiv · Nov 15, 2020 · PreprintCancer Biology

Decoupling tRNA promoter and processing activities enables specific Pol-II Cas9 guide RNA expression

D. J. Knapp, Y. S. Michaels, M. Jamilly, Q. R. Ferry, H. Barbosa, T. A. Milne, T. A. Fulga

The paper identifies sequence determinants of tRNA promoter and processing activities to engineer a Pol-II promoter for specific guide RNA expression.

bioRxiv · Jun 8, 2018Bioengineering