Author

A. J. Russell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 5 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:drug response / drug discovery· 4 Organism:human· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Organism:C. elegans· 2 Research Focus:cell type annotation· 2 Research Focus:clustering· 1

Frequent Co-Authors

D. B. Sattelle· 4 shared F. A. Partridge· 4 shared K. J. Else· 4 shared R. Forman· 4 shared C. J. R. Bataille· 3 shared G. M. Wynne· 3 shared N. J. Willis· 3 shared A. E. Brown· 2 shared

Activity by Year

2017-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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4 shared papersPharmacology & Toxicology

D. B. Sattelle

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Author profile →

6 papers

Recent·Most cited

HDAC inhibitor derivatives induce differentiation of leukemic cells through two distinct and separable mechanisms

P. Kumar, L. Josa-Cullere, T. R. Jackson, C. J. R. Bataille, P. Vyas, T. A. Milne, A. J. Russell

The paper shows HDAC inhibitors induce AML cell differentiation via two distinct mechanisms: one through G1 arrest and another through G2 arrest via Aurora A and GSK3 inhibition.

bioRxiv · Jan 6, 2024 · PreprintPharmacology & Toxicology

Screening the Medicines for Malaria Pandemic Response Box chemical library on Caenorhabditis elegans identifies re-profiled candidate anthelmintic drug leads

M. Nick, F. A. Partridge, R. Forman, C. J. R. Bataille, K. J. Else, A. J. Russell, D. B. Sattelle

The paper screens a chemical library on C. elegans to identify potential anthelmintic drug leads effective against parasitic nematodes.

bioRxiv · Aug 10, 2022 · PreprintPharmacology & Toxicology

Structural requirements for dihydrobenzoxazepinone anthelmintics: actions against medically important and model parasites - Trichuris muris, Brugia malayi, Heligmosomoides polygyrus and Schistosoma mansoni

F. A. Partridge, C. J. Bataille, R. Forman, A. E. Marriott, J. Forde-Thomas, C. Häberli, R. L. Dinsdale, J. D. O'Sullivan, N. J. Willis, G. M. Wynne, H. Whiteland, J. Archer, A. Steven, J. D. Turner, J. Keiser, , D. B. Sattelle

The paper investigates the structure-activity relationship of dihydrobenzoxazepinone (DHB) compounds against various parasitic nematodes and trematodes, identifying key structural features for anthelmintic activity.

ACS Infectious Diseases · Apr 2, 2021Peer-reviewedPharmacology & Toxicology

A chemical tool for improved culture of human pluripotent stem cells

L. Silpa, M. Schuessler, G. Liu, M. Olivecrona, L. Groizard-Payeras, E. Couper, C. J. R. Bataille, M. Stevenson, L. W. Seymour, S. G. Davies, W. S. James, S. A. Cowley, A. J. Russell

This paper identifies a small molecule, OXS8360, that improves the culture of human pluripotent stem cells by disrupting cell-cell contacts without affecting pluripotency or differentiation.

bioRxiv · Jan 24, 2020 · PreprintCell Biology

2,4-Diaminothienopyrimidines, a new class of anthelmintic with activity against adult and egg stages of whipworm

F. A. Partridge, R. Forman, N. J. Willis, C. J. Bataille, E. A. Murphy, A. E. Brown, N. Heyer-Chauhan, B. Marinic, D. J. Sowood, G. M. Wynne, K. J. Else, A. J. Russell, D. B. Sattelle

This paper identifies a new class of anthelmintic compounds, DATPs, effective against whipworm adult and egg stages, suggesting potential for environmental control strategies.

bioRxiv · Apr 26, 2018Pharmacology & Toxicology

An automated high-throughput system for phenotypic screening of chemical libraries on C. elegans and parasitic nematodes

F. A. Partridge, A. E. Brown, S. D. Buckingham, N. J. Willis, G. M. Wynne, R. Forman, K. J. Else, A. A. Morrison, J. B. Matthews, A. J. Russell, D. A. Lomas, D. B. Sattelle

The paper develops an automated system for screening chemical libraries against nematodes, identifying known and novel anthelmintic compounds.

bioRxiv · Sep 11, 2017Pharmacology & Toxicology