Author

T. R. Kleyman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Assay:electrophysiology· 1 Organism:human· 1

Frequent Co-Authors

A. L. Marciszyn· 4 shared E. C. Ray· 3 shared A. R. Subramanya· 2 shared A. Winfrey· 2 shared T. Lam· 2 shared A. Bleyer· 1 shared A. Jordahl· 1 shared A. Porter· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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4 shared papersPhysiology

A. L. Marciszyn

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4 papers

Recent·Most cited

Excess dietary sodium partially restores salt and water homeostasis caused by loss of the endoplasmic reticulum molecular chaperone, GRP170, in the mouse nephron

A. Porter, H. E. Vorndran, A. L. Marciszyn, S. M. Mutchler, A. R. Subramanya, T. R. Kleyman, L. M. Hendershot, J. L. Brodsky, T. M. Buck

This study shows that excess dietary sodium partially restores electrolyte imbalance and kidney injury markers in GRP170-deficient mice but not weight or tubule integrity.

bioRxiv · Jan 13, 2024 · PreprintCell Biology

Influence of MUC1 on trafficking of TRPV5 and TRPV6 and in vivo Ca2+ homeostasis.

M. M. Al-Bataineh, C. L. Kinlough, A. L. Marciszyn, T. Lam, L. Ye, K. Kidd, J. C. Maggiore, P. A. Poland, A. Bleyer, D. J. Bain, T. R. Kleyman, R. P. Hughey, E. C. Ray

This study investigates how MUC1 affects TRPV5 and TRPV6 trafficking and Ca2+ homeostasis, finding that MUC1 reduces endocytosis of these channels and influences blood Ca2+ levels in mice and humans.

bioRxiv · Oct 22, 2022 · PreprintPhysiology

Water and Electrolyte Homeostasis in a Mouse Model with Reduced ENaC Gamma Subunit Expression

E. C. Ray, A. Jordahl, A. L. Marciszyn, A. Winfrey, T. Lam, Y. Barak, S. Sheng, T. R. Kleyman

This study examines the role of the ENaC gamma subunit in electrolyte and fluid homeostasis using a mouse model with reduced gamma subunit expression, finding altered responses to dietary changes and fluid balance.

bioRxiv · Jan 26, 2021Physiology

L-WNK1 is required for BK channel activation in intercalated cells

E. C. Ray, R. Carrisoza, M. Al-Bataineh, A. L. Marciszyn, L. Nkashama, J. C. Chen, A. Winfrey, D. Flores, P. Wu, W. C. Wang, c.-l. wang, A. R. Subramanya, T. R. Kleyman, L. M. Satlin

This study shows that L-WNK1 in intercalated cells enhances BK channel activity in response to a high K+ diet, which is critical for urinary K+ secretion.

bioRxiv · Jan 26, 2021Physiology