Lgr5-mediated restraint of β-catenin is essential for B-lymphopoiesis and leukemia-initiation
K. N. Cosgun, M. E. Robinson, G. Deb, X. Yang, G. Xiao, T. Sadras, J. Lee, L. N. Chan, K. Kume, J. Winchester, Z. Chen, L. Yang, M. Mueschen
This study identifies Lgr5's role in restraining β-catenin to support B-lymphopoiesis and shows its therapeutic potential in B-ALL by targeting β-catenin hyperactivation.
bioRxiv · Mar 12, 2020 · PreprintCancer Biology