Glial Reactivity and Cognitive Decline Follow Chronic Heterochromatin Loss in Neurons
Andrew G. Newman, Jafar Sharif, Paraskevi Bessa, Sami Zaqout, Josie Brown, D. Richter, R. Dannenberg, Manabu Nakayama, Susanne G. Mueller, T. Schaub, Shairam Manickaraj, Philipp Boehm‐Sturm, Osamu Ohara, Haruhiko Koseki, Prim B. Singh, Victor S. Tarabykin
The paper shows chronic heterochromatin loss in neurons leads to ERV de-repression, inflammation, and cognitive decline in mice.
Nature Communications · Aug 8, 2025Peer-reviewedNeuroscience