Author

Jafar Sharif

RIKEN Center for Integrative Medical SciencesORCID 0000-0003-0422-3597Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1

Frequent Co-Authors

Haruhiko KosekiiD· 3 shared Aleksandar RakovićiD· 1 shared Andrew G. NewmaniD· 1 shared Aurélien GinolhaciD· 1 shared Borja Gomez RamosiD· 1 shared Christian ThomeiD· 1 shared Christine KleiniD· 1 shared Cláudia SaraivaiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersNeuroscience

Haruhiko KosekiORCID

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3 papers

Recent·Most cited

Molecular BiologybioRxivPreprintMar 27, 2026

Identification of Parkinson's disease-associated regulatory variants in human dopaminergic neurons reveals modulators of SCARB2 and BAG3 expression

Déborah Gérard, Jochen Ohnmacht, Borja Gomez Ramos…·Lasse Sinkkonen

The paper identifies Parkinson's disease-associated regulatory variants in human dopaminergic neurons and shows they modulate SCARB2 and BAG3 expression.

DOI 10.64898/2026.03.26.714241

humanbulk RNA-seq

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NeuroscienceNature CommunicationsPeer-reviewedAug 8, 2025

Glial Reactivity and Cognitive Decline Follow Chronic Heterochromatin Loss in Neurons

Andrew G. Newman, Jafar Sharif, Paraskevi Bessa…·Victor S. Tarabykin

The paper shows chronic heterochromatin loss in neurons leads to ERV de-repression, inflammation, and cognitive decline in mice.

9 citations

mouseDNA methylation

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NeuroscienceGliaPeer-reviewedMar 9, 2022

Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality.

Sònia Sabaté‐Soler, Sarah Nickels, Cláudia Saraiva…·Jens Christian Schwamborn

This study integrates human iPSC-derived microglia into midbrain organoids, enhancing neuronal maturation and functionality through effects on synaptic remodeling and excitability.

184 citationstop 1%

humanbulk RNA-seq

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