Author

T. Schoofs

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 3 Approach:experimental assay· 2 Organism:human· 2 Research Focus:protein structure prediction· 2 Approach:biophysical modeling· 1 Assay:cryo-EM· 1 Approach:microscopy & imaging analysis· 1 Assay:protein structure· 1

Frequent Co-Authors

M. C. Nussenzweig· 3 shared C. O. Barnes· 2 shared P. J. Bjorkman· 2 shared A. Gazumyan· 1 shared A. M. Hurley· 1 shared A. P. West· 1 shared A. Piechocka-Trocha· 1 shared B. D. Walker· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersImmunology

M. C. Nussenzweig

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3 papers

Recent·Most cited

HIV-1 CD4-binding site germline antibody-Env structures inform vaccine design

K.-M. A. Dam, C. O. Barnes, H. B. Gristick, T. Schoofs, M. C. Nussenzweig, P. J. Bjorkman

The paper uses cryo-EM to study germline antibody-Env structures to identify key interactions and guide vaccine design.

bioRxiv · Mar 25, 2022Biochemistry

A naturally arising broad and potent CD4-binding site antibody with low somatic mutation

C. O. Barnes, T. Schoofs, P. N. P. Gnanapragasam, J. Golijanin, K. E. Huey-Tubman, H. Gruell, P. Schommers, N. Suh-Toma, Y. E. Lee, J. C. C. Lorenzi, A. Piechocka-Trocha, J. F. Scheid, A. P. West, B. D. Walker, M. S. Seaman, , P. J. Bjorkman

This paper describes a VRC01-class antibody with lower somatic mutation but comparable breadth and potency to other broadly neutralizing antibodies against HIV-1.

bioRxiv · Mar 16, 2022Immunology

Public broadly neutralizing antibodies against hepatitis B virus in individuals with elite serologic activity

Q. Wang, E. Michailidis, Y. Yu, Z. Wang, A. M. Hurley, D. A. Oren, C. T. Mayer, A. Gazumyan, Z. Liu, Y. Zhou, T. Schoofs, K.-h. Yao, J. Nieke, J. Wu, Q. Jiang, , M. C. Nussenzweig

The paper identifies broadly neutralizing antibodies against HBV in elite neutralizers and shows that combinations of bNAbs targeting different epitopes are more effective than single bNAbs.

bioRxiv · Mar 4, 2020 · PreprintImmunology