Author

H. B. Gristick

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 6 Approach:experimental assay· 5 Organism:non-human primate· 3 Assay:structural biology· 2 Assay:cryo-EM· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1 Organism:mouse· 1

Frequent Co-Authors

P. J. Bjorkman· 6 shared M. C. Nussenzweig· 5 shared M. A. Martin· 4 shared A. Escolano· 3 shared A. P. West· 3 shared C. O. Barnes· 3 shared K.-M. A. Dam· 3 shared M. S. Seaman· 3 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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6 shared papersImmunology

P. J. Bjorkman

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6 papers

Recent·Most cited

CD4-binding site immunogens elicit heterologous anti-HIV-1 neutralizing antibodies in transgenic and wildtype animals

H. B. Gristick, H. Hartweger, M. Loewe, J. van Schooten, V. Ramos, T. Y. Oliviera, Y. Nishimura, N. S. Koranda, A. Wall, K.-H. Yao, D. Poston, A. Gazumyan, M. Wiatr, M. Horning, J. R. Keeffe, , P. J. Bjorkman

This study shows that CD4bs immunogens can elicit potent, broad anti-HIV-1 neutralizing antibodies in transgenic and wildtype animals.

bioRxiv · Sep 8, 2022Immunology

HIV-1 CD4-binding site germline antibody-Env structures inform vaccine design

K.-M. A. Dam, C. O. Barnes, H. B. Gristick, T. Schoofs, M. C. Nussenzweig, P. J. Bjorkman

The paper uses cryo-EM to study germline antibody-Env structures to identify key interactions and guide vaccine design.

bioRxiv · Mar 25, 2022Biochemistry

Neutralizing antibodies induced in immunized macaques recognize the CD4-binding site on an occluded-open HIV-1 envelope trimer

Z. Yang, K.-M. A. Dam, M. D. Bridges, M. A. G. Hoffmann, A. T. DeLaitsch, H. B. Gristick, A. Escolano, R. Gautam, M. A. Martin, M. Nussenzweig, W. Hubbell, P. J. Bjorkman

This study identifies two antibodies from immunized macaques that neutralize HIV-1 by targeting the CD4-binding site on an occluded-open Env trimer conformation.

bioRxiv · Nov 2, 2021Immunology

Antibody elicited by HIV-1 immunogen vaccination in macaques displaces Env fusion peptide and destroys a neutralizing epitope

M. E. Abernathy, H. B. Gristick, J. Vielmetter, J. R. Keeffe, P. N. Gnanapragasam, Y. E. Lee, A. Escolano, R. Gautam, M. S. Seaman, M. A. Martin, M. C. Nussenzweig, P. J. Bjorkman

This study identifies an off-target antibody that displaces the HIV-1 Env fusion peptide and blocks neutralizing epitopes, providing insights for vaccine design.

bioRxiv · Mar 17, 2021Immunology

A Broadly Neutralizing Macaque Monoclonal Antibody Against the HIV-1 V3-Glycan Patch

Z. Wang, C. O. Barnes, R. Gautam, J. C. Cetrulo Lorenzi, C. T. Mayer, T. Y. Oliveira, V. Ramos, M. Cipolla, K. M. Gordon, H. B. Gristick, A. P. West, Y. Nishimura, H. Raina, M. S. Seaman, A. Gazumyan, , M. C. Nussenzweig

This paper reports a broadly neutralizing monoclonal antibody from a macaque infected with SHIVAD8 that targets the V3-glycan patch of HIV-1 Env, showing neutralizing activity and protective efficacy in vivo.

bioRxiv · Aug 10, 2020Immunology

Structures of human antibodies bound to SARS-CoV-2 spike reveal common epitopes and recurrent features of antibodies

C. O. Barnes, A. P. West, K. Huey-Tubman, M. A. G. Hoffmann, N. G. Sharaf, P. R. Hoffman, N. Koranda, H. B. Gristick, C. Gaebler, F. Muecksch, J. C. Cetrulo Lorenzi, S. Finkin, T. Hagglof, A. Hurley, K. G. Millard, , P. J. Bjorkman

bioRxiv · May 28, 2020Immunology