Author

C. T. Mayer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Assay:proteomics· 4 Organism:human· 3 Research Focus:cell type annotation· 2 Organism:mouse· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

Q. Wang· 3 shared A. Gazumyan· 2 shared J. Wu· 2 shared M. C. Nussenzweig· 2 shared M. J. Willett· 2 shared Y. Zhou· 2 shared Z. Wang· 2 shared A. Escolano· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersImmunology

Q. Wang

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5 papers

Recent·Most cited

Peripheral death by neglect and limited clonal deletion during physiologic B lymphocyte development

M. J. Willett, C. McNees, S. Sharma, A. M. Newen, D. Pfannenstiel, T. Moyer, D. Stephany, I. Douagi, Q. Wang, C. T. Mayer

The paper quantifies apoptosis and clonal deletion during B lymphocyte development, finding that most peripheral B cell death results from failed selection rather than clonal deletion.

bioRxiv · May 30, 2023 · PreprintImmunology

Fortuitous Somatic Mutations during Antibody Evolution Endow Broad Neutralization against SARS-CoV-2 Omicron Variants

J. Wu, Z. Chen, Y. Gao, Z. Wang, J. Wang, B.-Y. Chiang, Y. Zhou, Y. Han, W. Zhan, M. Xie, W. Jiang, X. Zhang, A. Hao, A. Xia, J. He, , Q. Wang

The paper identifies an antibody with broad neutralization against SARS-CoV-2 Omicron variants and shows how somatic mutations enhance its neutralization breadth and potency.

Cell Reports · May 1, 2023Peer-reviewedImmunology

Antigen receptor signaling and cell death resistance controls intestinal humoral response zonation.

F. Raso, S. Liu, M. J. Willett, G. Barton, C. T. Mayer, O. Bannard, M. Acharya, J. Muppidi, A. Marshak-Rothstein, A. Reboldi

This study shows that IgA BCR signaling enhances B cell fitness and promotes diverse IgA responses to gut commensals by rescuing low-affinity B cells and redirecting plasma cell homing.

bioRxiv · Mar 16, 2023Immunology

A Broadly Neutralizing Macaque Monoclonal Antibody Against the HIV-1 V3-Glycan Patch

Z. Wang, C. O. Barnes, R. Gautam, J. C. Cetrulo Lorenzi, C. T. Mayer, T. Y. Oliveira, V. Ramos, M. Cipolla, K. M. Gordon, H. B. Gristick, A. P. West, Y. Nishimura, H. Raina, M. S. Seaman, A. Gazumyan, , M. C. Nussenzweig

This paper reports a broadly neutralizing monoclonal antibody from a macaque infected with SHIVAD8 that targets the V3-glycan patch of HIV-1 Env, showing neutralizing activity and protective efficacy in vivo.

bioRxiv · Aug 10, 2020Immunology

Public broadly neutralizing antibodies against hepatitis B virus in individuals with elite serologic activity

Q. Wang, E. Michailidis, Y. Yu, Z. Wang, A. M. Hurley, D. A. Oren, C. T. Mayer, A. Gazumyan, Z. Liu, Y. Zhou, T. Schoofs, K.-h. Yao, J. Nieke, J. Wu, Q. Jiang, , M. C. Nussenzweig

The paper identifies broadly neutralizing antibodies against HBV in elite neutralizers and shows that combinations of bNAbs targeting different epitopes are more effective than single bNAbs.

bioRxiv · Mar 4, 2020 · PreprintImmunology