D. Bojkova

Repurposing of the antibiotic nitroxoline for the treatment of mpox

This study shows nitroxoline, an antibiotic, inhibits mpox virus replication and remains effective against tecovirimat-resistant strains, suggesting it as a repurposing candidate for mpox treatment.

Omicron-induced interferon signalling prevents influenza A virus infection

This study shows Omicron variants induce interferon responses in human cells, protecting against influenza A virus super-infection, while Delta does not.

Synergism of interferon-beta with antiviral drugs against SARS-CoV-2 variants

This study evaluates the antiviral efficacy of interferon-beta combined with antiviral drugs against SARS-CoV-2 variants, finding synergistic effects with certain drugs against specific variants.

Identification of novel antiviral drug candidates using an optimized SARS-CoV-2 phenotypic screening platform

This study develops a phenotypic screening platform using caspase 3/7 activity to identify antiviral compounds against SARS-CoV-2, including novel candidates and combinations.

Development and optimisation of a high-throughput screening assay for in vitro anti-SARS-CoV-2 activity: evaluation of 5676 phase 1 passed structures

The paper develops a high-throughput screening assay to evaluate 5676 phase 1 compounds for in vitro anti-SARS-CoV-2 activity, identifying eight candidates but finding only remdesivir suitable for further clinical development.

USP22 controls type III interferon signaling and SARS-CoV-2 infection through activation of STING

This study identifies USP22 as a regulator of STING and type III IFN signaling, showing its role in SARS-CoV-2 infection and antiviral defense in human intestinal epithelial cells.

SARS-CoV-2 Omicron variant virus isolates are highly sensitive to interferon treatment

This study shows that SARS-CoV-2 Omicron variants are more sensitive to interferon treatment than Delta variants, suggesting interferons could be effective therapies for Omicron infections.

Reduced interferon antagonism but similar drug sensitivity in Omicron variant compared to Delta variant SARS-CoV-2 isolates

This study compares drug sensitivity and interferon antagonism between Omicron and Delta SARS-CoV-2 variants, finding similar drug responses but reduced interferon antagonism in Omicron.

Differences between intrinsic and acquired nucleoside analogue resistance in acute myeloid leukaemia cells

This study identifies intrinsic and acquired resistance mechanisms to CNDAC and related nucleoside analogues in AML cells, showing distinct roles of SAMHD1 and DCK.

CD47 as a potential biomarker for the early diagnosis of severe COVID-19

This study identifies CD47 as a potential biomarker for early diagnosis of severe COVID-19 by showing its increased levels in SARS-CoV-2 infection and association with risk factors and complications.

Characterization of protease activity of Nsp3 from SARS-CoV-2 and its in vitro inhibition by nanobodies

This study characterizes Nsp3 protease activity from SARS-CoV-2 and identifies nanobodies that inhibit PLpro with nanomolar affinity.

In Vitro Activity of Itraconazole Against SARS-CoV-2

This paper assesses the in vitro antiviral activity of itraconazole and its metabolite against SARS-CoV-2, finding EC50 values of 2.3 μM and 3.6 μM, respectively, and reports no clinical efficacy in hospitalized patients.

Evaluation of stability and inactivation methods of SARS-CoV-2 in context of laboratory settings

This study evaluates inactivation methods for SARS-CoV-2 in laboratory settings, finding that some lysis buffers and chemical treatments effectively inactivate the virus, while others do not.

Targeting pentose phosphate pathway for SARS-CoV-2 therapy

This study identifies the pentose phosphate pathway as a target for SARS-CoV-2 therapy and shows that inhibiting it with benfooxythiamine reduces viral replication.

COVID-19-related coagulopathy, is transferrin a missing link?

The paper identifies transferrin as a potential coagulation promoter in COVID-19, showing age-related increases, sex differences, and upregulation upon infection.

SARS-CoV-2 infects and induces cytotoxic effects in human cardiomyocytes

This study shows SARS-CoV-2 infects human cardiomyocytes, causing cytotoxicity and apoptosis, and confirms this in cardiac tissue models.

Optimized qRT-PCR approach for the detection of intra- and extracellular SARS-CoV-2 RNAs

This study presents an optimized qRT-PCR method for detecting SARS-CoV-2 RNA using a low-cost SYBR green approach, showing improved detection limits and simplicity compared to multi-step assays.

SARS-CoV-2 and SARS-CoV differ in their cell tropism and drug sensitivity profiles

This study compares SARS-CoV-2 and SARS-CoV in cell tropism and drug sensitivity, finding differences in conservation, receptor usage, and therapeutic responses to aprotinin and remdesivir.