Author

T. Tsujino

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Pathology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Approach:genetic perturbation / CRISPR· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. S. Kibel· 2 shared C. Miao· 2 shared K. W. Mouw· 2 shared L. Jia· 2 shared T. Takai· 2 shared T. Tsutsumi· 2 shared Z. Szallasi· 2 shared A. D. Choudhury· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

A. S. Kibel

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

CRISPR screens reveal genetic determinants of PARP inhibitor sensitivity and resistance in prostate cancer

T. Tsujino, T. Takai, K. Hinohara, F. Gui, T. Tsutsumi, X. Bai, C. Miao, C. Feng, B. Gui, S. Sztupinszki, A. Simoneau, N. Xie, L. Fazli, X. Dong, H. Azuma, , L. Jia

This study uses CRISPR screens to identify genetic factors affecting PARP inhibitor sensitivity and resistance in prostate cancer, revealing novel targets and mechanisms.

bioRxiv · Apr 13, 2022 · PreprintCancer Biology

Iron Deficiency Induces Heart Failure with Ectopic Cardiac Calcification in Mice with Metabolic Syndrome

Y. Naito, H. Sawada, S. Yasumura, T. Horimatsu, K. Okuno, S. Tahara, K. Nishimura, M. Asakura, T. Tsujino, T. Masuyama, M. Ishihara

This study shows that iron deficiency in mice with metabolic syndrome causes heart failure with ectopic cardiac calcification, which is reduced by etidronate.

bioRxiv · Jan 20, 2022Pathology

RB1 loss overrides PARP inhibitor sensitivity driven by RNASEH2B loss in prostate cancer

c. Miao, T. Tsujino, T. Takai, G. Fu, T. Tsutsumi, Z. Sztupinszki, Z. Szallasi, K. W. Mouw, A. S. Kibel, L. Jia

The paper shows that loss of RNASEH2B makes prostate cancer cells sensitive to PARP inhibitors, but co-deletion with RB1 reduces this sensitivity through BRCA2 upregulation, and ATR inhibition can restore sensitivity.

bioRxiv · Nov 8, 2021Cancer Biology