T. Takai

Structural and Dynamic Insights into the Biased Signaling Mechanism of the Human Kappa Opioid Receptor

This study investigates the structural dynamics of the human KOR-Gi signaling complex with G-protein-biased and balanced agonists, identifying key residues involved in signaling bias.

NMR analysis of the homodimeric structure of a D-Ala-D-Ala metallopeptidase, VanX, from vancomycin-resistant bacteria

The paper determines the dimeric structure of VanX using NMR and identifies a monomeric form for inhibitor screening.

TLR7/8 stress response drives histiocytosis in SLC29A3 disorders

This study identifies TLR7/8 as drivers of histiocytosis in SLC29A3 disorders by responding to lysosomal nucleoside stress and enhancing monocyte proliferation and phagocyte maturation.

CRISPR screens reveal genetic determinants of PARP inhibitor sensitivity and resistance in prostate cancer

This study uses CRISPR screens to identify genetic factors affecting PARP inhibitor sensitivity and resistance in prostate cancer, revealing novel targets and mechanisms.

RB1 loss overrides PARP inhibitor sensitivity driven by RNASEH2B loss in prostate cancer

The paper shows that loss of RNASEH2B makes prostate cancer cells sensitive to PARP inhibitors, but co-deletion with RB1 reduces this sensitivity through BRCA2 upregulation, and ATR inhibition can restore sensitivity.

Synergy between a shallow root system with a DRO1 homologue and localized P application improves rice P uptake

This study shows that combining a shallow root system with localized phosphorus application enhances phosphorus uptake in rice.

Subcellular localization of glypican-5 associates with dynamic cell motility and cell communication of the human mesenchymal stem cell line U3DT

The paper investigates the subcellular localization of GPC5 in U3DT cells and links its distribution to cell motility and communication.