T. V. Mishanina

This study shows that the Alx protein, regulated by a riboswitch, exports excess Mn2+ in E. coli under alkaline conditions to maintain intracellular Mn2+ homeostasis.

This study defines an interconverting ensemble of ePEC states using cryo-EM and biochemical analysis, showing that ePECs occupy pre- or half-translocated states without always swiveling.

This study identifies the elemental pause mechanism in transcription by showing it is multipartite, causes a conformational shift, and can transition into backtracked states.

This study determines the structural basis of how NusG and RfaH regulate transcript elongation by suppressing backtracking and pausing in bacterial RNA polymerase complexes.