D. Nayak

Epigenetic disruption of the RARγ complex impairs its function to bookmark AR enhancer interactions required for enzalutamide sensitivity in prostate cancer

This study identifies RARγ's role in bookmarking AR enhancer interactions in prostate cancer, showing its impact on enzalutamide sensitivity and lineage plasticity.

First complete genome characterization of an Indian pigeon pox virus directly from a clinical sample

The paper reports the first complete genome of an Indian pigeon pox virus and performs comparative genomics analysis to understand its genetic features and phylogenetic relationships.

The MYC axis in advanced prostate cancer is impacted through concurrent targeting of ERβ and AR using a novel ERβ-selective ligand alongside Enzalutamide

This study shows that combining a novel ERβ ligand with Enzalutamide reduces MYC signaling and growth in advanced prostate cancer.

Retinoic Acid Inducible Gene-I like Receptors Activate Snail and Slug to Limit RNA Viral Infections

The paper shows that RLRs activate Snail and Slug to limit RNA viral infections by regulating their transcription and enhancing the antiviral response.

Ebselen derivatives are very potent dual inhibitors of SARS-CoV-2 proteases - PLpro and Mpro in in vitro studies

This study identifies ebselen derivatives as potent inhibitors of SARS-CoV-2 proteases PLpro and Mpro in vitro, with some compounds showing greater potency than ebselen itself.

Activity profiling and structures of inhibitor-bound SARS-CoV-2-PLpro protease provides a framework for anti-COVID-19 drug design

This study profiles SARS-CoV-2-PLpro activity and determines inhibitor structures to guide anti-COVID-19 drug design.

The elemental mechanism of transcriptional pausing

This study identifies the elemental pause mechanism in transcription by showing it is multipartite, causes a conformational shift, and can transition into backtracked states.