Author

T. Zacharchenko

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

B. T. Goult· 2 shared C. Ballestrem· 1 shared C. Jorgensen· 1 shared G. Jacquemet· 1 shared J. D. Humphries· 1 shared J. Yan· 1 shared M. C. Jones· 1 shared M. Humphries· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBiochemistry

B. T. Goult

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2 papers

Recent·Most cited

The structural basis of the Talin-KANK1 interaction that coordinates the actin and microtubule cytoskeletons at focal adhesions.

X. Li, B. T. Goult, C. Ballestrem, T. Zacharchenko

This paper determines the structure of the talin-KANK1 complex, revealing how KANK1 binds talin and its localization in focal adhesions is regulated by actomyosin tension.

bioRxiv · Feb 23, 2023Biochemistry

Talin mechanosensitivity is modulated by a direct interaction with cyclin-dependent kinase-1

R. E. Gough, M. C. Jones, T. Zacharchenko, S. Le, M. Yu, G. Jacquemet, s. P. muench, J. Yan, J. D. Humphries, C. Jorgensen, M. Humphries, B. T. Goult

This study identifies a direct interaction between CDK1 and talin at integrin adhesions, showing CDK1 modulates talin's mechanosensitivity and affects downstream mechanotransduction.

bioRxiv · Mar 19, 2021Cell Biology