Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
13 papers
Recent·Most cited
M. Kang, Y. Otani, Y. Guo, J. Yan, B. T. Goult, A. K. Howe
This study identifies talin1 as a mechanically-gated AKAP that binds PKA through a force-dependent interaction in focal adhesions.
Proceedings of the National Academy of Sciences · Mar 21, 2024Peer-reviewedCell Biology
N. J. Ball, S. Ghimire, G. Follain, A. O. Pajari, M. Vaitkeviciute, A. R. Cowell, B. Berki, J. Ivaska, I. Paatero, B. T. Goult, G. Jacquemet
This study identifies TLNRD1 as a CCM complex component that regulates endothelial barrier integrity by modulating actin bundling.
bioRxiv · Sep 29, 2023Cell Biology
M. V. Chanduri, A. Kumar, D. Weiss, N. Emuna, I. Barsukov, M. Shi, K. Tanaka, X. Wang, A. Datye, J. Kanyo, F. Collin, T. Lam, U. D. Schwarz, S. Bai, T. Nottoli, , M. A. Schwartz
This study shows that mutations in talin1 alter cellular stiffness sensing, leading to changes in ECM mechanical properties and aortic compliance.
bioRxiv · Sep 3, 2023 · PreprintCell Biology
X. Liu, Y. Wang, M. Yao, K. B. Baker, B. Klapholz, N. H. T. Brown, B. T. Goult, J. Yan
This study examines vinculin's mechanical properties, finding it unfolds and refolds in response to force, suggesting it acts as a mechanotransducer.
bioRxiv · May 25, 2023 · PreprintBiophysics
L. M. Gallego-Paez, W. J. S. Edwards, Y. Guo, M. Chanduri, T. Koorman, C.-Y. Lee, N. Grexa, P. W. B. Derksen, J. Yan, M. A. Schwartz, J. Mauer, B. T. Goult
The paper identifies a cancer-associated exon in TLN1 that alters mechanosensitivity by affecting R1-R2 switch dynamics and vinculin binding.
Journal of Cell Biology · Mar 6, 2023Peer-reviewedCancer Biology
X. Li, B. T. Goult, C. Ballestrem, T. Zacharchenko
This paper determines the structure of the talin-KANK1 complex, revealing how KANK1 binds talin and its localization in focal adhesions is regulated by actomyosin tension.
bioRxiv · Feb 23, 2023Biochemistry
M. Miihkinen, A. Popovic, S. Ghimire, R. Saup, M. Grönloh, N. Ball, B. T. Goult, J. Ivaska, G. Jacquemet
The paper identifies lamellipodin as a novel cargo of myosin-X and shows it is transported to filopodia tips to support their formation and stability.
bioRxiv · Aug 17, 2022 · PreprintCell Biology
Y. Wang, M. Yao, K. B. Baker, R. E. Gough, S. Le, B. T. Goult, J. Yan
This study investigates how mechanical forces affect talin-vinculin interactions, showing that force exposure of a vinculin binding site relieves vinculin autoinhibition and enhances binding affinity.
bioRxiv · Apr 26, 2021Biophysics
R. E. Gough, M. C. Jones, T. Zacharchenko, S. Le, M. Yu, G. Jacquemet, s. P. muench, J. Yan, J. D. Humphries, C. Jorgensen, M. Humphries, B. T. Goult
This study identifies a direct interaction between CDK1 and talin at integrin adhesions, showing CDK1 modulates talin's mechanosensitivity and affects downstream mechanotransduction.
bioRxiv · Mar 19, 2021Cell Biology
S. J. Han, E. V. Azarova, A. J. Whitewood, A. Bachir, E. Guttierrez, A. Groisman, A. R. Horwitz, B. T. Goult, K. Dean, G. Danuser
The paper shows that talin's precomplex with vinculin accelerates adhesion maturation by enhancing vinculin recruitment and force transmission.
bioRxiv · Jan 4, 2021 · PreprintCell Biology
A. R. Cowell, G. Jacquemet, A. K. Singh, Y.-C. Ammon, D. G. Brown, A. Akhmanova, J. Ivaska, B. T. Goult
This study identifies TLNRD1 as an actin-bundling protein that promotes filopodia formation and cell migration by interacting with LD-motif proteins like RIAM and KANK.
bioRxiv · May 19, 2020Cell Biology
M. Miihkinen, M. L. B. Grönloh, H. Vihinen, E. Jokitalo, B. T. Goult, J. Ivaska, G. Jacquemet
The paper identifies MYO10 and talin as key regulators of integrin activity in filopodia, proposing a two-step model for integrin activation.
bioRxiv · May 5, 2020Cell Biology
L. Azizi, A. Cowell, V. V. Mykuliak, B. T. Goult, P. Turkki, V. P. Hytonen
This study analyzes talin-1 mutations from the COSMIC database to assess their impact on cell adhesion, migration, and cancer progression using bioinformatics and experimental approaches.
bioRxiv · Mar 25, 2020Cancer Biology