G. Jacquemet

TLNRD1 is a CCM complex component and regulates endothelial barrier integrity

This study identifies TLNRD1 as a CCM complex component that regulates endothelial barrier integrity by modulating actin bundling.

Proteomic profiling of isolated immune synapses from primary mouse B cells

This study isolates and profiles immune synapses from primary mouse B cells to identify proteins involved in early activation by surface-bound antigens, revealing novel components and pathways.

Vimentin enables directional cell migration by coordinating focal adhesion organization and dynamics

This study shows vimentin stabilizes focal adhesion alignment during directed fibroblast migration, enabling persistent directional movement.

Targeting a broad spectrum of KRAS-mutant cancers by hyperactivation-induced cell death

This study identifies SHANK3 as a RAS interactor that limits oncogenic KRAS signaling, and shows that disrupting its interaction with KRAS induces cell death in KRAS-mutant cancers.

Myosin-X recruits lamellipodin to filopodia tips

The paper identifies lamellipodin as a novel cargo of myosin-X and shows it is transported to filopodia tips to support their formation and stability.

Regulation of cell dynamics by rapid transport of integrins through the biosynthetic pathway

This study shows that integrin transport through the biosynthetic pathway rapidly alters adhesion receptor availability, enabling localized cell spreading and focal adhesion growth.

High-fidelity 3D live-cell nanoscopy through data-driven enhanced super-resolution radial fluctuation

This paper introduces eSRRF, an enhanced super-resolution imaging method that improves image fidelity and extends to 3D imaging using multi-focus microscopy.

DeepBacs: Bacterial image analysis using open-source deep learning approaches

DeepBacs uses open-source deep learning to analyze bacterial microscopy images, offering tools for segmentation, classification, and phenotyping with applications in antibiotic research.

Filopodia-mediated basement membrane assembly at pre-invasive tumor boundaries

This study shows MYO10 promotes BM assembly in DCIS to limit invasion but facilitates cancer cell dissemination in invasive breast cancer.

Talin mechanosensitivity is modulated by a direct interaction with cyclin-dependent kinase-1

This study identifies a direct interaction between CDK1 and talin at integrin adhesions, showing CDK1 modulates talin's mechanosensitivity and affects downstream mechanotransduction.

Conformational dynamics regulate SHANK3 actin and Rap1 binding

This study shows SHANK3 binds actin and Rap1 through its SPN domain, with conformational changes regulating this interaction and affecting cellular processes like filopodia formation and autism-related phenotypes.

Cargo-specific recruitment in clathrin and dynamin-independent endocytosis

The paper identifies swiprosin-1 as a cargo-specific adaptor for the CG-pathway, showing its role in integrin internalization and breast cancer progression.

Automated cell tracking using StarDist and TrackMate

This paper presents an automated cell tracking pipeline using StarDist and TrackMate for 2D live-cell imaging, applicable to fluorescent and brightfield images without coding knowledge.

Talin Rod Domain Containing Protein 1 (TLNRD1) is a novel actin- bundling protein which promotes filopodia formation

This study identifies TLNRD1 as an actin-bundling protein that promotes filopodia formation and cell migration by interacting with LD-motif proteins like RIAM and KANK.

Myosin-X and talin modulate integrin activity at filopodia tips

The paper identifies MYO10 and talin as key regulators of integrin activity in filopodia, proposing a two-step model for integrin activation.

Fluctuation-based Super-Resolution Traction Force Microscopy

This paper introduces a method to improve traction force microscopy resolution and throughput using super-resolution microscopy based on fluorophore fluctuation analysis.

Filopodome mapping identifies p130Cas as a mechanosensitive regulator of filopodia stability

The paper maps filopodia adhesions using structured illumination microscopy and identifies p130Cas as a mechanosensitive regulator of filopodia stability.

FiloQuant reveals increased filopodia density during DCIS progression

FiloQuant quantifies filopodia density and dynamics in various cell types and microenvironments, revealing increased filopodia density during DCIS progression.