Author

J. D. Humphries

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell-cell communication· 2 Organism:human· 2 Assay:proteomics· 2

Frequent Co-Authors

M. J. Humphries· 4 shared C. Jorgensen· 3 shared M. C. Jones· 3 shared D. Knight· 2 shared M. R. Chastney· 2 shared A. Bermudez· 1 shared A. Kerr· 1 shared A. Mironov· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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4 shared papersCancer Biology

M. J. Humphries

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Lineage plasticity in SCLC generates non-neuroendocrine cells primed for vasculogenic mimicry

S. M. Pearsall, S. C. Williamson, F. J. Garcia Marques, S. Humphrey, E. Hughes, Y. T. Shue, A. Bermudez, K. Frese, M. Galvin, M. Carter, L. Preist, A. Kerr, C. Zhou, T. G. Oliver, J. D. Humphries, , C. Dive

This study identifies VM-competent non-neuroendocrine cells in SCLC that support vessel formation and tumor growth through integrin β1-dependent ECM remodeling.

Journal of Thoracic Oncology · Oct 1, 2023Peer-reviewedCancer Biology

Pancreatic ductal adenocarcinoma cells employ integrin α6β4 to form hemidesmosomes and regulate cell proliferation

J. D. Humphries, J. Zha, J. Burns, J. A. Askari, C. R. Below, M. R. Chastney, M. C. Jones, A. Mironov, D. Knight, D. A. O'Reilly, M. J. Dunne, D. R. Garrod, C. Jorgensen, M. J. Humphries

This study identifies integrin α6β4 and hemidesmosomes as critical for PDAC cell proliferation and ECM organization, with implications for therapeutic targeting.

bioRxiv · Aug 19, 2021Cancer Biology

Talin mechanosensitivity is modulated by a direct interaction with cyclin-dependent kinase-1

R. E. Gough, M. C. Jones, T. Zacharchenko, S. Le, M. Yu, G. Jacquemet, s. P. muench, J. Yan, J. D. Humphries, C. Jorgensen, M. Humphries, B. T. Goult

This study identifies a direct interaction between CDK1 and talin at integrin adhesions, showing CDK1 modulates talin's mechanosensitivity and affects downstream mechanotransduction.

bioRxiv · Mar 19, 2021Cell Biology

A SNAI2-PEAK1 stromal axis drives progression and lapatinib resistance in HER2-positive breast cancer by supporting a cytokine expression profile that converges on PI3K/Akt signaling

S. Hamalian, R. Güth, F. Runa, J. Molnar, E. Vickers, M. Agajanian, J. D. Humphries, M. J. Humphries, J. C. Tchou, I. Zervantonakis, J. Kelber

bioRxiv · May 15, 2020Cancer Biology

Definition of the fibroblast adhesome using multiplexed proximity biotinylation

M. R. Chastney, C. Lawless, J. D. Humphries, S. Warwood, M. C. Jones, D. Knight, C. Jorgensen, M. J. Humphries

The paper defines the fibroblast adhesome using multiplexed proximity biotinylation and identifies functional modules within integrin adhesion complexes.

bioRxiv · Jan 24, 2020Cell Biology