Author

R. E. Gough

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Approach:microscopy & imaging analysis· 2 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1 Assay:imaging· 1 Research Focus:protein folding & dynamics· 1 Research Focus:transcription & RNA processing· 1

Frequent Co-Authors

A. dos Santos· 2 shared B. T. Goult· 2 shared C. P. Toseland· 2 shared J. Arron· 2 shared J. Yan· 2 shared L. Wang· 2 shared M. L. Martin-Fernandez· 2 shared N. Fili· 2 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersBiophysics

A. dos Santos

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Binding partners regulate unfolding of myosin VI to activate the molecular motor

A. dos Santos, N. Fili, Y. Hari-Gupta, R. E. Gough, L. Wang, M. L. Martin-Fernandez, J. Arron, E. Wait, T. L. Chew, C. P. Toseland

This study investigates how binding partners regulate myosin VI unfolding and activation through biochemical and single-molecule analyses of splice isoforms.

Biochemical Journal · Jul 4, 2022Peer-reviewedBiophysics

Force-dependent interactions between talin and full-length vinculin

Y. Wang, M. Yao, K. B. Baker, R. E. Gough, S. Le, B. T. Goult, J. Yan

This study investigates how mechanical forces affect talin-vinculin interactions, showing that force exposure of a vinculin binding site relieves vinculin autoinhibition and enhances binding affinity.

bioRxiv · Apr 26, 2021Biophysics

Talin mechanosensitivity is modulated by a direct interaction with cyclin-dependent kinase-1

R. E. Gough, M. C. Jones, T. Zacharchenko, S. Le, M. Yu, G. Jacquemet, s. P. muench, J. Yan, J. D. Humphries, C. Jorgensen, M. Humphries, B. T. Goult

This study identifies a direct interaction between CDK1 and talin at integrin adhesions, showing CDK1 modulates talin's mechanosensitivity and affects downstream mechanotransduction.

bioRxiv · Mar 19, 2021Cell Biology

Nuclear myosin VI regulates the spatial organization of mammalian transcription initiation.

Y. Hari-Gupta, N. Fili, A. dos Santos, A. W. Cook, R. E. Gough, H. C. W. Reed, L. Wang, J. Arron, T. Venit, E. Waite, A. Grosse-Berkenbusch, J. C. M. Gebhardt, P. Percipalle, T. L. Chew, M. L. Martin-Fernandez, C. P. Toseland

This study identifies nuclear myosin VI as a molecular anchor for RNA Polymerase II clusters, showing its role in maintaining transcription factory organization and gene expression.

bioRxiv · Apr 21, 2020Cell Biology