Author

T.-H. Hsiao

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Assay:metabolomics· 2 Organism:mouse· 2 Assay:proteomics· 2 Assay:metagenomics· 1

Frequent Co-Authors

P.-H. Wang· 4 shared Y.-L. Chen· 4 shared Y.-R. Chiang· 4 shared T.-H. Lee· 3 shared C.-H. Chou· 2 shared C.-J. Shih· 2 shared M. Horinouchi· 2 shared M. Meng· 2 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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4 shared papersMicrobiology

P.-H. Wang

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4 papers

Recent·Most cited

Clostridium innocuum, an opportunistic gut pathogen, inactivates host gut progesterone and arrests ovarian follicular development

M.-J. Chen, C.-H. Chou, T.-H. Hsiao, T.-Y. Wu, C.-Y. Li, Y.-L. Chen, K.-H. Chao, T.-H. Lee, R. Gicana, C.-J. Shih, G.-J. Brandon-Mong, Y.-L. Lai, P.-T. Li, Y.-L. Tseng, P.-H. Wang, Y.-R. Chiang

This study identifies Clostridium innocuum as a gut bacterium that inactivates progesterone by converting it to epipregnanolone, leading to decreased serum progesterone and follicular arrest in mice.

Gut Microbes · Nov 7, 2024Peer-reviewedMicrobiology

Circulating androgen regulation by androgen-catabolizing gut bacteria in male mouse gut

T.-H. Hsiao, C.-H. Chou, Y.-L. Chen, P.-H. Wang, G.-J. B. Mong, T.-H. Lee, T.-Y. Wu, P.-T. Li, C.-W. Li, Y.-L. Lai, Y.-L. Tseng, C.-J. Shih, M.-J. Chen, Y.-R. Chiang

This study shows that oral administration of Thauera sp. strain GDN1 reduces serum androgen levels in male mice by catabolizing androgens in the gut.

bioRxiv · Jul 20, 2022Microbiology

Identification of essential β-oxidation genes and corresponding metabolites for estrogen degradation by actinobacteria

T.-H. Hsiao, T.-H. Lee, M.-R. Chuang, P.-H. Wang, M. Meng, M. Horinouchi, T. Hayashi, Y.-L. Chen, Y.-R. Chiang

This study identifies essential β-oxidation genes and metabolites involved in estrogen degradation by actinobacteria using transcriptomics, gene disruption, and metabolite profiling.

bioRxiv · Apr 22, 2021Microbiology

Genetic and metabolite biomarkers reveal actinobacteria-mediated estrogen biodegradation in urban estuarine sediment

T.-H. Hsiao, Y.-L. Chen, M. Meng, M.-R. Chuang, M. Horinouchi, T. Hayashi, P.-H. Wang, Y.-R. Chiang

This study identifies actinobacterial genes and metabolites involved in estrogen degradation in urban estuarine sediments and finds actinobacteria, not proteobacteria, are primarily responsible for estrogen breakdown.

bioRxiv · Oct 7, 2020 · PreprintMicrobiology