Clostridium innocuum, an opportunistic gut pathogen, inactivates host gut progesterone and arrests ovarian follicular development
M.-J. Chen, C.-H. Chou, T.-H. Hsiao, T.-Y. Wu, C.-Y. Li, Y.-L. Chen, K.-H. Chao, T.-H. Lee, R. Gicana, C.-J. Shih, G.-J. Brandon-Mong, Y.-L. Lai, P.-T. Li, Y.-L. Tseng, P.-H. Wang, Y.-R. Chiang
This study identifies Clostridium innocuum as a gut bacterium that inactivates progesterone by converting it to epipregnanolone, leading to decreased serum progesterone and follicular arrest in mice.
Gut Microbes · Nov 7, 2024Peer-reviewedMicrobiology