Author

Y.-R. Chiang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 7 Ecology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 6 Assay:metabolomics· 3 Organism:bacteria (other)· 2 Assay:metagenomics· 2 Organism:mouse· 2 Assay:proteomics· 2 Approach:statistical model· 2

Frequent Co-Authors

Y.-L. Chen· 7 shared P.-H. Wang· 6 shared T.-H. Lee· 5 shared T.-H. Hsiao· 4 shared T.-Y. Wu· 4 shared Y.-L. Lai· 3 shared C.-H. Chou· 2 shared C.-J. Shih· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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7 shared papersMicrobiology

Y.-L. Chen

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Clostridium innocuum, an opportunistic gut pathogen, inactivates host gut progesterone and arrests ovarian follicular development

M.-J. Chen, C.-H. Chou, T.-H. Hsiao, T.-Y. Wu, C.-Y. Li, Y.-L. Chen, K.-H. Chao, T.-H. Lee, R. Gicana, C.-J. Shih, G.-J. Brandon-Mong, Y.-L. Lai, P.-T. Li, Y.-L. Tseng, P.-H. Wang, Y.-R. Chiang

This study identifies Clostridium innocuum as a gut bacterium that inactivates progesterone by converting it to epipregnanolone, leading to decreased serum progesterone and follicular arrest in mice.

Gut Microbes · Nov 7, 2024Peer-reviewedMicrobiology

Circulating androgen regulation by androgen-catabolizing gut bacteria in male mouse gut

T.-H. Hsiao, C.-H. Chou, Y.-L. Chen, P.-H. Wang, G.-J. B. Mong, T.-H. Lee, T.-Y. Wu, P.-T. Li, C.-W. Li, Y.-L. Lai, Y.-L. Tseng, C.-J. Shih, M.-J. Chen, Y.-R. Chiang

This study shows that oral administration of Thauera sp. strain GDN1 reduces serum androgen levels in male mice by catabolizing androgens in the gut.

bioRxiv · Jul 20, 2022Microbiology

Identification of essential β-oxidation genes and corresponding metabolites for estrogen degradation by actinobacteria

T.-H. Hsiao, T.-H. Lee, M.-R. Chuang, P.-H. Wang, M. Meng, M. Horinouchi, T. Hayashi, Y.-L. Chen, Y.-R. Chiang

This study identifies essential β-oxidation genes and metabolites involved in estrogen degradation by actinobacteria using transcriptomics, gene disruption, and metabolite profiling.

bioRxiv · Apr 22, 2021Microbiology

Integrated multi-omics investigations reveal the key role of synergistic microbial networks in removing plasticizer di-(2-ethylhexyl) phthalate from estuarine sediments

S. T.-S. Wei, Y.-L. Chen, Y.-W. Wu, T.-Y. Wu, Y.-L. Lai, P.-H. Wang, W. Ismail, T.-H. Lee, Y.-R. Chiang

This study identifies synergistic microbial networks in estuarine sediments that degrade DEHP, with Acidovorax and Sedimenticola as key degraders and horizontal gene transfer playing a role in DEHP degradation capacity.

bioRxiv · Mar 24, 2021Microbiology

Genetic and metabolite biomarkers reveal actinobacteria-mediated estrogen biodegradation in urban estuarine sediment

T.-H. Hsiao, Y.-L. Chen, M. Meng, M.-R. Chuang, M. Horinouchi, T. Hayashi, P.-H. Wang, Y.-R. Chiang

This study identifies actinobacterial genes and metabolites involved in estrogen degradation in urban estuarine sediments and finds actinobacteria, not proteobacteria, are primarily responsible for estrogen breakdown.

bioRxiv · Oct 7, 2020 · PreprintMicrobiology

Long-term warming weakens stabilizing effects of biodiversity in aquatic ecosystems

C.-W. Chang, H. Ye, T. Miki, E. R. Deyle, S. Souissi, O. Anneville, R. Adrian, Y.-R. Chiang, S. Ichise, M. Kumagai, S.-i. S. Matsuzaki, F.-K. Shiah, J.-T. Wu, C.-h. Hsieh, G. Sugihara

The paper examines how long-term warming reduces the stabilizing role of biodiversity in aquatic ecosystems by analyzing time series data and causal relationships.

bioRxiv · Jan 6, 2020 · PreprintEcology

Retroconversion of estrogens into androgens by bacteria via a cobalamin-mediated methylation

P.-H. Wang, Y.-L. Chen, S. T.-S. Wei, K. Wu, T.-H. Lee, T.-Y. Wu, Y.-R. Chiang

The paper identifies a bacterial strain capable of converting estrogens into androgens via cobalamin-mediated methylation, revealing a novel metabolic pathway.

bioRxiv · Jul 25, 2019Microbiology

Genome analysis of the steroid-degrading denitrifying Denitratisoma oestradiolicum DSM 16959 and Denitratisoma sp. strain DHT3

Y.-L. Chen, S. Wei, Y.-R. Chiang

The paper presents the genomes of two anaerobic estrogen-degrading bacteria and identifies genes involved in their steroid degradation pathways.

bioRxiv · Jul 22, 2019 · PreprintMicrobiology