Author

T.-Y. Kuo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 4 Research Focus:drug response / drug discovery· 3 Research Focus:benchmarking· 1 Assay:protein structure· 1 Assay:proteomics· 1 Organism:rat· 1

Frequent Co-Authors

C. Chen· 5 shared M.-Y. Lin· 5 shared Y.-J. Lin· 5 shared L. T. C. Liu· 4 shared C.-C. Wu· 3 shared C.-E. Lien· 3 shared J. D. Campbell· 3 shared P. Traquina· 3 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersImmunology

C. Chen

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Neutralization of SARS-CoV-2 Omicron BA.4/BA.5 subvariant by a booster dose of bivalent adjuvanted subunit vaccine containing Omicron BA.4/BA.5 and BA.1 subvariants

T.-Y. Kuo, C. E. Lien, Y.-J. Lin, M.-Y. Lin, L. T.-C. Liu, C.-C. Wu, W.-H. Tang, C. Chen

This study evaluates the effectiveness of a bivalent subunit vaccine containing Omicron BA.4/BA.5 and BA.1 subvariants as a booster, finding it provides the highest neutralizing titers against BA.4/BA.5 in mice.

bioRxiv · Oct 7, 2022 · PreprintImmunology

Protection of Hamsters Challenged with SARS-CoV-2 after Two Doses of MVC-COV1901 Vaccine Followed by a Single Intranasal Booster with Nanoemulsion Adjuvanted S-2P Vaccine

Y.-J. Lin, M.-Y. Lin, Y.-S. Chuang, L. T. C. Liu, T.-Y. Kuo, C. Chen, S. Ganesan, A. Fattom, V. Bitko, C.-E. Lien

This study shows that a two-dose intramuscular vaccine followed by an intranasal booster provides strong protection against SARS-CoV-2 in hamsters, reducing viral load and disease symptoms.

bioRxiv · Feb 24, 2022Immunology

Protection of Hamsters Challenged with SARS-CoV-2 Variants of Concern by Two Doses of MVC-COV1901 Vaccine Followed by a Single Dose of Beta Variant Version of MVC-COV1901

T.-Y. Kuo, C.-E. Lien, Y.-J. Lin, M.-Y. Lin, C.-C. Wu, W.-H. Tang, J. D. Campbell, P. Traquina, Y.-S. Chuang, L. T. C. Liu, J. Cheng, C. Chen

This study evaluates the efficacy of a vaccine regimen using wildtype and Beta variant S-2P in hamsters against SARS-CoV-2 Delta and VoCs, showing improved neutralization and protection with a mixed-dose schedule.

bioRxiv · Sep 29, 2021 · PreprintImmunology

CpG-adjuvanted stable prefusion SARS-CoV-2 spike protein protected hamsters from SARS-CoV-2 challenge

C.-E. Lien, Y.-J. Lin, C. Chen, W.-C. Lian, T.-Y. Kuo, J. D. Campbell, P. Traquina, M.-Y. Lin, L. T. C. Liu, Y.-S. Chuang, H.-Y. Ku, C.-C. Liao, Y.-H. Chen, J.-T. Jan, C.-P. Sun, , Y.-L. Lin

This study shows that CpG-adjuvanted S-2P vaccine protected hamsters from SARS-CoV-2 infection by inducing high neutralizing antibodies and reducing viral load.

bioRxiv · Jan 7, 2021Microbiology

Development of CpG-adjuvanted stable prefusion SARS-CoV-2 spike antigen as a subunit vaccine against COVID-19

T.-Y. Kuo, M.-Y. Lin, R. L. Coffman, J. D. Campbell, P. Traquina, Y.-J. Lin, L. T. C. Liu, J. Cheng, Y.-C. Wu, C.-C. Wu, W.-H. Tang, C.-G. Huang, K.-C. Tsao, S.-R. Shih, C. Chen

This paper develops a subunit vaccine against COVID-19 using CpG-adjuvanted stable prefusion SARS-CoV-2 spike antigen and shows it induces high neutralizing antibody titers and Th1 response in mice.

bioRxiv · Aug 11, 2020Immunology