Y.-C. Wu

Syngeneic natural killer cell therapy activates dendritic and T cells in metastatic lungs and effectively treats low-burden metastases

This study shows that autologous NK cell therapy activates dendritic and T cells in metastatic lungs and effectively treats low-burden metastases in a mouse model and a clinical trial.

Dietary bacteria control C. elegans fat content through pathways converging at phosphatidylcholine

This study identifies how dietary vitamin B12 influences phosphatidylcholine metabolism in C. elegans, affecting fat content through pathways involving SAM, PC, and regulatory proteins.

Increased multiplexity in optical tissue clearing-based 3D immunofluorescence microscopy of the tumor microenvironment by LED photobleaching

This paper introduces an LED photobleaching method to enhance 3D immunofluorescence microscopy multiplexity for tumor microenvironment analysis, achieving 8-plex imaging.

Avoidance learning reduces intricate covariation between boldness and foraging behavior in a generalist predator

This study examines how avoidance learning affects the relationship between boldness and foraging behavior in lizards, finding that learning reduces individual variation and covariation in behavior.

Auxin Plays a Role in the Adaptation of Rice to Anaerobic Germination and Seedling Establishment

This study shows that auxin accumulation under submergence inhibits rice root and leaf growth but promotes coleoptile elongation, with miR167-ARF-GH3 pathway regulating IAA levels to affect anaerobic germination tolerance.

Phylogenetic reconciliation reveals extensive ancestral recombination in Sarbecoviruses and the SARS-CoV-2 lineage

The paper introduces virDTL, a phylogenetic workflow for analyzing viral evolution with recombination, and applies it to Sarbecoviruses to identify ancestral recombination events in SARS-CoV-2.

The Most Parsimonious Reconciliation Problem in the Presence of Incomplete Lineage Sorting and Hybridization is NP-Hard

This paper proves that the maximum parsimony reconciliation problem for gene trees and species networks is NP-hard when considering deep coalescence.

Intermittent KHz-frequency electrical stimulation selectively engages small unmyelinated vagal afferents

This study identifies intermittent KHz-frequency electrical stimulation (KES) as a method to selectively engage small unmyelinated vagal C-afferents in rats and mice.

Grazing results in mobilization of spherulous cells and re-allocation of secondary metabolites to the surface in the sponge Aplysina aerophoba

This study examines how the sponge Aplysina aerophoba responds to grazing by Tylodina perversa and mechanical damage, revealing similar wounding responses and secondary metabolite reallocation.

A Polynomial-Time Algorithm for Minimizing the Deep Coalescence Cost for Level-1 Species Networks

This paper presents a polynomial-time algorithm for reconciling gene trees with level-1 species networks, improving efficiency in phylogenetic network reconstruction.

MAP kinase Slt2p attenuates cell wall mRNA decay by downregulating the RNA-binding protein Rbp1p in response to stress

This study shows that Slt2p MAP kinase reduces cell wall mRNA decay by decreasing Rbp1p activity during cell wall stress.

Development of CpG-adjuvanted stable prefusion SARS-CoV-2 spike antigen as a subunit vaccine against COVID-19

This paper develops a subunit vaccine against COVID-19 using CpG-adjuvanted stable prefusion SARS-CoV-2 spike antigen and shows it induces high neutralizing antibody titers and Th1 response in mice.

Epigenetic therapy remodels the immune synaptic cytoskeleton to potentiate cancer susceptibility to γδ T cells

DNA methyltransferase inhibitors enhance γδ T cell-mediated lung cancer killing by remodeling immune synaptic cytoskeletal networks.