A nuclear branched-chain amino acid catabolism pathway controls histone propionylation in pancreatic cancer
Christina Demetriadou, Michael Noji, Austin L. Good, Erick Mitchell-Velasquez, Sharan Venkatesh, Daniel S. Kantner, Jennifer L Pennise, Pedro Costa‐Pinheiro, Laura V. Pinheiro, Taku Harada, Phuong Trang Nguyen, Adam G. Chatoff, Emily Megill, Claudia Veronica Da Silva Crispim, Mariola M. Marcinkiewicz, , Kathryn E. Wellen
This study identifies a nuclear branched-chain amino acid catabolism pathway in pancreatic cancer that regulates histone propionylation and gene expression.
bioRxiv · Apr 23, 2025 · PreprintCancer Biology