Author

Takuya Kumazawa

Harvard University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cell Biology· 1

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Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:metabolism & bioenergetics· 1 Organism:mouse· 1

Frequent Co-Authors

Aaron I. WeineriD· 1 shared Bin HeiD· 1 shared Chia‐Wei ChengiD· 1 shared Chiakang HoiD· 1 shared Ji-Won LeeiD· 1 shared Konrad HochedlingeriD· 1 shared Murat ÇetinbaşiD· 1 shared Nabeel M. BardeesyiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCell Biology

Aaron I. WeinerORCID

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1 paper

Recent·Most cited

Metformin inhibits nuclear egress of chromatin fragments in senescence and aging

Takuya Kumazawa, Yanxin Xu, Yu Wang, Ji-Won Lee, Tara C. O’Brien, Chiakang Ho, Murat Çetinbaş, Aaron I. Weiner, Konrad Hochedlinger, Ruslan I. Sadreyev, Nabeel M. Bardeesy, Chia‐Wei Cheng, Bin He, Zhixun Dou

This study shows metformin inhibits chromatin fragment egress from the nucleus, reducing cGAS-STING activation and chronic inflammation in aging.

Nature Aging · Jan 16, 2026Peer-reviewedCell Biology