Konrad Hochedlinger

This study shows metformin inhibits chromatin fragment egress from the nucleus, reducing cGAS-STING activation and chronic inflammation in aging.

This study reveals bidirectional fate transitions between myeloid-biased and lineage-balanced hematopoietic stem cells using clonal phylogenetic tracing.

The paper identifies a point of irreversible commitment in granulocytic differentiation and shows how chromatin state dynamics and transcription factor feedback loops influence this decision.

This study shows that CAF-1 maintains myeloid lineage identity by regulating chromatin accessibility and transcription factor control during differentiation.

This paper demonstrates that epigenetic reprogramming using OSK genes can reverse age-related and injury-induced vision loss in mice by resetting DNA methylation patterns and promoting axon regeneration.

Optimal transport converts a 65,781-cell reprogramming time course into probabilistic fates and trajectories, exposing alternative cell fates and a gene, Obox6, that improves reprogramming efficiency.